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Annotation

Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature . 2009 Jun 4 ; 459(7247):698-702. PubMed Abstract

Comments on Paper and Primary News
Primary News: Commentary Brief: Optogenetics Links Interneurons and γ Oscillations

Comment by:  Guillermo Gonzalez-Burgos
Submitted 24 July 2009 Posted 24 July 2009

Blue light, yellow light, and the role of parvalbumin-positive neurons in the pathophysiology of schizophrenia
Parvalbumin (PV)-positive cells are a prominent subtype of GABA neuron that via perisomatic synapses may strongly inhibit pyramidal cell activity (however, see Szabadics et al., 2006). In schizophrenia, PV neurons have reduced levels of mRNA for PV and for GAD67, the 67 kilodalton form of the GABA-synthesizing enzyme glutamate decarboxylase. The functional consequences of the PV reduction in schizophrenia are poorly understood, but one possibility is that decreased PV partially compensates for a deficit in GABA release caused by the GAD67 reduction. PV is a slow Ca2+ buffer, and so decreasing PV in nerve terminals may facilitate GABA release during repetitive PV cell firing (for a review, see Gonzalez-Burgos and Lewis, 2008).

Why is PV cell-mediated inhibition significant to brain function? What deficits in cortical circuit function may be compensated for (at...  Read more


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