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Annotation

Bassett DS, Bullmore E, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A. Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci . 2008 Sep 10 ; 28(37):9239-48. PubMed Abstract

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Comment by:  Peter Uhlhaas
Submitted 29 September 2008 Posted 1 October 2008
  I recommend this paper

Increasing evidence is emerging that the functional and anatomical organization of the human brain follows a “small-world architecture” that involves a high degree of local clustering and selective long-range connections. This architecture allows both for segregated and distributed neural processing and enables an energy efficient processing mode in the cortex (Achard et al., 2006). Small-world properties are not confined to the human brain, however, but have been found in non-human primates and indeed in many other complex systems (see Bassett and Bullmore, 2006, for a review).

The current study by Bassett et al. (2008) provides important new evidence that the application of this approach may yield crucial insights into the pathophysiology of schizophrenia. In their study, Bassett and colleagues examined MRI data from 259 healthy volunteers and 203 scans from patients with schizophrenia. By analyzing the correlations of cortical thickness across subjects, the authors were able...  Read more


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