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Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-Oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet . 2008 Oct 15 ; 17(20):3212-22. PubMed Abstract

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Comment by:  Atsushi Kamiya
Submitted 7 August 2008 Posted 7 August 2008

Recent advances in genetic studies in psychiatry have identified many candidate factors that may alter susceptibility to schizophrenia. Biological studies have begun to clarify that some of them may contribute to common disease pathways in brain development.

DISC1 is one of the major genetic susceptibility candidates for schizophrenia. It is a multifunctional protein that interacts with other molecules related to neurodevelopment. Ikeda and colleagues (Ikeda et al., 2008) conducted a genetic association study for several DISC1 interacting factors, including NDEL1, LIS1, 14-3-3 epsilon (YWHAE), Grb2, and KIF5A. They reported the association of six SNPs of YWHAE with schizophrenia, but no association of SNPs in other molecules in their sample sets. Given that one of the six SNPs is located in the 5’ flanking region of YWHAE, the authors hypothesize that it may have functional effects. They obtained evidence for a correlation between this SNP and expression levels of YWHAE in lymphocytes of health control subjects. Ikeda and...  Read more

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