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Kruglikov I, Rudy B. Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators. Neuron . 2008 Jun 26 ; 58(6):911-24. PubMed Abstract

Comments on Paper and Primary News
Primary News: Down With Inhibition: Modulating GABAergic Neocortical Control

Comment by:  Miles Whittington
Submitted 24 July 2008 Posted 24 July 2008

This paper by Kruglikov and Rudy examines in detail the profile of neuromodulatory influences on GABA release from fast-spiking (FS), parvalbumin-containing interneurons in sensory neocortex. The work elegantly demonstrates that this interneuron subtype is exquisitely sensitive to a diverse range of neuromodulatory chemicals including those acting on muscarinic, purinergic, serotonergic, and GABAB receptors. Agonists at each of these receptors produced a strong inhibition of GABA release from electrically stimulated FS synaptic terminals and, as a result, reduced inhibitory influence both locally in cortex and on ascending thalamocortical projections. These interneurons are of particular interest currently in schizophrenia research as functional markers for them are found to be robustly reduced in postmortem brain samples from schizophrenic patients. They are also one of the key interneuron subtypes involved in the generation of certain EEG rhythms—in particular, those in the gamma (30-80 Hz) band—involved in primary sensory processing, short-term...  Read more

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