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Annotation

Fisahn A, Neddens J, Yan L, Buonanno A. Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia. Cereb Cortex . 2009 Mar 1 ; 19(3):612-8. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Kevin Spencer (Disclosure)
Submitted 24 February 2009 Posted 24 February 2009

The recent interest in gamma oscillations as biomarkers of neural circuit function in schizophrenia was spurred by the convergence between neurophysiological experiments in animal models and human post-mortem studies. These studies have found strong evidence that fast-spiking, perisomatic-targeting inhibitory interneurons, which express the calcium-binding protein parvalbumin (PV), are critically involved in the generation of gamma rhythms (Whittington and Traub, 2003), and may also be particularly affected in schizophrenia (Gonzalez-Burgos and Lewis, 2008). It has been thought that this link is strengthened by the reports of abnormalities in several gamma oscillations recorded from schizophrenia patients, compared to healthy individuals. In various studies, the power and/or phase synchronization of gamma oscillations has been found to be reduced in schizophrenia patients (e.g., Brenner et al., 2003; Cho et al., 2006; Ford et al., 2007; Hong et al., 2004; Light et al., 2006; Spencer et al., 2008a, b; Teale et al., 2008).

A recently published study by Fisahn et al. (2009)...  Read more


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Comment by:  Richard Deth
Submitted 24 February 2009 Posted 25 February 2009
  I recommend this paper

Interestingly, dopamine D4 receptors mediate neureglin-1 effects on LTP, and D4 receptor variants have also been shown to influence gamma frequency power.

References:

Kwon OB, Paredes D, Gonzalez CM, Neddens J, Hernandez L, Vullhorst D, Buonanno A. Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15587-92. Abstract

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