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Annotation

Abbas A, Roth BL. Arresting serotonin. Proc Natl Acad Sci U S A . 2008 Jan 22 ; 105(3):831-2. PubMed Abstract

Comments on Paper and Primary News
Primary News: Hidden Complexity Seen in Serotonin Signaling

Comment by:  Patricia Estani
Submitted 23 February 2008 Posted 26 February 2008
  I recommend this paper

Primary News: Hidden Complexity Seen in Serotonin Signaling

Comment by:  Atheir Abbas
Submitted 25 February 2008 Posted 27 February 2008
  I recommend this paper

Implicit in the findings of Schmid et al. is the idea that the relationship among ligand, receptor signaling, and cellular context is an extremely complex one that will take a great deal more work to tease out. Thus, Dr. Bryan Roth has proposed on a number of occasions (see, for example, Gray and Roth, 2007; Abbas and Roth, 2005) that novel approaches for drug discovery may prove more effective in producing schizophrenia drugs that have greater therapeutic efficacy with lower side effect liability. Since it will likely be many years before the field has a detailed understanding of the "nitty-gritty" of the receptor signaling and trafficking relevant to schizophrenia and its treatment, we have suggested a number of approaches that are less reliant on such information.

For example, approaches based on screening for drugs that either mimic the gene expression profiles of gold standard drugs such as clozapine or normalize schizophrenia-associated changes in gene expression are being...  Read more


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