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Konopaske GT, Dorph-Petersen KA, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol Psychiatry . 2008 Apr 15 ; 63(8):759-65. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Lennart Borgman
Submitted 27 May 2012 Posted 29 May 2012
  I recommend this paper

I am a bit confused about the dose of antipsychotics given to the monkeys in the study. I have heard some researchers say that the monkeys got a high dose, but that seems wrong to me. In the section "Drug Preparation and Administration" in the paper, the authors say:

"Consequently, in this study, we sought to obtain plasma levels of 1-1.5 ng/ml for haloperidol and of 10-25 ng/ml for olanzapine."

The authors refer to McEvoy et al. (McEvoy et al., 1986; McEvoy et al., 1991) and their concept of "neuroleptic threshold dosing." The chosen plasma levels should correspond to this.

Is this not a low dose? And is it not actually much lower than the doses used in schizophrenia treatment?

I would be glad for any comment on this. Thanks.


McEvoy JP, Hogarty GE, Steingard S (1991). Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Arch Gen Psychiatry 48: 739-745. Abstract

McEvoy JP, Stiller RL, Farr R (1986). Plasma haloperidol levels drawn at neuroleptic threshold doses: a pilot study. J Clin Psychopharmacol 6: 133-138. Abstract

View all comments by Lennart Borgman

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