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Annotation

Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci . 2007 Oct 17 ; 27(42):11254-62. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Dennis GraysonErminio Costa
Submitted 14 November 2007 Posted 14 November 2007

Comment by Dennis R. Grayson, Erminio Costa, and Alessandro Guidotti
Schizophrenia is a devastating disorder with a population-wide morbidity approaching 1 percent. The genetics of this disease are perhaps the most studied facet of the disorder, but the results of multiple linkage analyses across the entire genome have provided only limited insight into the underlying etiological factors that hallmark the disease. While linkage studies are informative, problems associated with the interpretation of complex genetics make their interpretation difficult. In fact, the inconsistencies associated with the results of recent meta-analyses of genome-wide scans and large sib-pair studies indicate that there is no replicable support for any of the currently considered candidate genes (Crow, 2007). Recent thinking suggests that the origins of the disease may lie in DNA sequence variations coupled with epigenetic dysfunction as a key etiopathogenic factor.

Several studies point to a defect in GABAergic transmission as a key factor underlying the schizophrenia phenotype....  Read more


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