This is an interesting epidemiological finding. A...
This is an interesting epidemiological finding. A reproduction of this association in other populations would be needed. Of note, one of the autoantigens of type I diabetes (GAD, glutamic acid decarboxylase) is expressed in the nervous system and autoantibodies against GAD lead to a rare neurological disorder, Stiff-Person-Syndrome. Immunologically, type I diabetes is very complex, involving cellular and humoral immune effector mechanisms. How this may protect against the development of schizophrenia is not easily explained.
PRIMARY NEWSA Possible Protective Role for Type 1 Diabetes in Schizophrenia