Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Weis S, Llenos IC, Dulay JR, Elashoff M, Martínez-Murillo F, Miller CL. Quality control for microarray analysis of human brain samples: The impact of postmortem factors, RNA characteristics, and histopathology. J Neurosci Methods . 2007 Sep 30 ; 165(2):198-209. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Marquis Vawter
Submitted 21 September 2007 Posted 21 September 2007

This article by senior author Dr. Christine Miller and colleagues is one of several recent articles that demonstrate the rigorous assessments required to derive useful knowledge in high-throughput gene expression experiments. The well-known adage that “garbage in = garbage out” was not surprisingly demonstrated in this careful work by first author S. Weis et al.

The authors demonstrated many additional points. One salient point was the relationship of cerebellar acidosis and neuronal atrophy, i.e., as pH decreases there was more cerebellar granular cell layer necrosis. This finding is consistent with previous reports such as Dr. Paul Harrison’s 1995 work: “The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins” (Harrison et al., 1995) and even earlier studies of glutamic acid decarboxylase activity alterations in brain tissue from patients with Huntington's disease in the 1970s-1980s (  Read more

View all comments by Marquis Vawter
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright