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Annotation

[No authors listed]. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature . 2007 Jun 7 ; 447(7145):661-78. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Francis McMahon, SRF Advisor
Submitted 15 June 2007 Posted 18 June 2007
  I recommend this paper

This paper reports the results of a genome-wide association study of seven common diseases—including bipolar disorder—carried out by the Wellcome Trust Case Control Consortium (WTCCC). Although it comes at the end of a recent wave (tsunami?) of papers reporting genome-wide association results, this important work deserves careful study. Aficionados will appreciate the rich methodological detail and the careful approach to many issues—population stratification, the relationship of SNPs to genes, correction for multiple testing—that worry those of us who do these studies. Everyone will get a sense of the power of this new approach to detect genetic signals that have long eluded the best efforts of the field.

Although it returned fewer highly significant “hits” than most of the other diseases, the bipolar disorder sample (ably collected and phenotyped by Craddock and colleagues) nevertheless yielded many interesting findings. These are worthy of follow-up either by virtue of their statistical significance, apparent biological plausibility, or...  Read more


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