Schizophrenia Research Forum - A Catalyst for Creative Thinking

News Brief: Neuroanatomy of Functional Deficits in Schizophrenia

11 March 2007. An editorial in the March issue of the American Journal of Psychiatry, by editor Robert Freedman of the University of Colorado, Boulder, weaves together a discussion of six papers that probe brain regions and fiber pathways throughout the brain that might underlie specific deficits in people with schizophrenia. We note this editorial in particular because it reads much like one of our own news summaries, accessible to a large audience of readers, and also because access to the article is open to all readers, not just subscribers.

In his article, Freedman describes the individual take-home messages of these studies, and also sketches out some of the ways that they contribute to the daily challenge of living with schizophrenia. The studies probe the neuroanatomical substrates of the disease with functional or structural imaging technology or EEG, and link these findings to either endophenotypes (see SRF live discussion) of psychological function or to aspects of the phenotype, the clinical definition of the disease. "None of the articles, separately or together, give us the all-encompassing picture of schizophrenia that we seek, but each tells us something of how a part of the brain functions abnormally and what the psychological consequence of the malfunction appears to be," writes Freedman.

Freedman R. Neuronal dysfunction and schizophrenia symptoms. Am J Psychiatry. 2007 Mar;164(3):385-90. Abstract