Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Research News
back to News Search
GSK3β—Not Just for Tauists Anymore
Article appears by special arrangement with Alzheimer Research Forum. See original article with additional links/commentary.

30 January 2004. Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that features hallucinations—an occasional feature of AD—and obvious deficits in working memory? Here, then, is such a peek: A paper in Nature Genetics, wherein researchers implicate impaired signaling in the AKT1-GSK3β pathway in schizophrenia.

The tauophiles in the Alzheimer's research community have a longstanding interest in glycogen synthase kinase (GSK)3β because it is known to phosphorylate tau (see Alzheimer Research Forum related news story), and those more drawn to the amyloid camp have also begun to show interest in the GSK3α variant, which could be involved in the production of Aβ (see Alzheimer Research Forum related news story). GSK3β is well-studied due to its role in regulating insulin and β-catenin in the Wnt pathway.

The major factor controlling GSK3β activation is the protein-serine/threonine kinase AKT1, which has already come to interest AD researchers for its role in inhibiting apoptosis. And the researchers have been quick to note that AKT1 mediates phoshatidylinositol 3 (PI3) kinase signaling, which in turn is susceptible to Aβ control. Psychiatric disease researchers have turned their attention to AKT1, which appears to be a principal target of lithium and other drugs used in bipolar disorder. There is some evidence that the AKT gene increases risk for bipolar disorder. Given the evidence for overlapping genetic and biochemical abnormalities in bipolar disorder and schizophrenia, AKT1 is also of great interest in schizophrenia research.

In the current study, a multi-institutional team led by Joseph Gogos of Columbia University and Maria Karayiorgou of the Rockefeller University, both in New York City, went on an interesting "fishing expedition." They write, "We speculated that alterations in brain levels or activity of protein kinases and phosphatases may contribute to schizophrenia susceptibility in humans and that this might be observed in the peripheral tissues of individuals with schizophrenia." Assessing protein levels in peripheral blood lymphocytes, they focused on kinases implicated in synaptic plasticity, and were rewarded with the finding that levels of AKT1 protein were 68 percent lower in subjects with schizophrenia (P = 0.014). This went hand-in-hand with significant decreases in phosphorylation of the AKT1 target GSK3β both in peripheral lymphocytes and in postmortem tissue from frontal cortex of schizophrenia patients. In addition, AKT1 levels were reduced in the cortex of patients.

The site of the AKT1 gene, in the cytogenetic band 14q32, has never been fingered as a susceptibility locus in linkage scans of kindreds with schizophrenia. However, the authors found a significant association between schizophrenia and a haplotype of the AKT1 gene associated with lower protein levels. In another experiment, the authors turned to AKT1 -/- mice to investigate whether these show any abnormalities that might be relevant to schizophrenia. They indeed found that this knockout strain produced deficits in a measure of sensorimotor gating, a defect characteristic of schizophrenia. In addition, the authors showed in-vivo evidence that haloperidol, much like lithium, boosts phosphorylation of AKT1, evidence that the AKT1-GSK3β pathway could be a prime site of action for the antipsychotic medication.

As catalogued by the authors, AKT1 turns up as a player in many cellular processes, with links to important molecules (e.g., GABRA, BDNF, NRATC, calcineurin, neuregulin), and thus is poised to have wide influence. "This influence may be additive, perhaps due to small impairment of several processes, or may be restricted to a small number of key processes that are particularly AKT1 dosage-dependent. In any case, our data is consistent with a model in which impairment of AKT1-GSK3β signaling increases the liability of these neuronal circuits to additional genetic or environmental insults that ultimately lead to the disease," the authors conclude.—Hakon Heimer (Alzheimer Research Forum).

Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet. 2004 Jan 25 [Epub ahead of print]. Abstract

Submit a Comment on this News Article
Make a comment on this news article. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Copyright © 2005- 2016 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright