Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Research News
back to News Search Plain English
Overactive Dopamine Reworks Brain’s Wiring Diagram

October 16, 2013. Psychosis reflects disruptions in a complex, and only partly understood, set of brain circuits. One thing is well established, however—psychosis can be controlled with drugs that block the chemical messenger dopamine from interacting with one of its receptors, the D2 type. However, even when antipsychotic drugs completely quell psychosis, problems with thinking and motivation remain in people with schizophrenia. A new study published October 13 in Nature Neuroscience suggests a possible explanation—that these D2 receptors were overactive during childhood or early adolescence and reworked the usual brain-wiring diagram.

Zheng Li at the National Institute of Mental Health in Bethesda, Maryland, and colleagues found that D2 dopamine receptors in mice sculpt the shape of brain cells during this middle period of brain development, and that when they are overactive, they leave the cells with fewer places to receive messages from other cells. Consistent with this, and possibly relevant to schizophrenia, the researchers found that overactive D2 receptors during mouse "early adolescence" led to disrupted wiring and weakened memory in adulthood. (For more details, see SRF related news story.)—Michele Solis.

 
Submit a Comment on this News Article
Make a comment on this news article. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright