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News Brief—Dead End for Lilly mGluR Schizophrenia Drug

29 August 2012. Eli Lilly and Company announced in a press release today that they will stop Phase 3 clinical trials of a schizophrenia drug targeting the metabotropic glutamate receptor. This was not unexpected, as just last month Lilly had revealed further disappointing trial results of the mGluR2/3 agonist pomaglumetad methionil (also called LY2140023). At the time, researchers interviewed by SRF had mixed opinions about the way forward (see SRF news story), and a Lilly spokesperson had told SRF that they were still pressing forward with the development of LY2140023, including analyzing data on mGluR2/3 agonists as adjunctive therapy to approved schizophrenia drugs. In the latest press release, they write that this Phase 2 study also failed to meet its primary endpoint.—Hakon Heimer.

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