Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Research News
back to News Search
Commentary Brief: Optogenetics Links Interneurons and γ Oscillations

24 July 2009. For the past several years, a handful of research groups have been wowing neuroscience conference audiences with their slides on optogenetics, wherein neurons and their functions are controlled by light. You can read descriptions of the evolution of the technique in recent articles in the The New York Times and Nature; if you have time to watch videos, check out this lecture by Karl Deisseroth of Stanford University. We also have a recent SRF meeting report on the methodology from Victoria Heimer-Torres.

Recently, these techniques have been employed to study a population of cells of interest to a number of schizophrenia neurobiologists—the parvalbumin-expressing interneurons of the cortex. We asked Guillermo Gonzalez-Burgos of the University of Pittsburgh to explain the technique and its potential usefulness for research on psychiatric disorders, as well as to discuss the new findings that link these interneurons with cortical γ oscillations. This work, which appeared as two papers in the June 4 issue of Nature, was performed by Deisseroth and his colleagues at Stanford, as well as in a collaboration between Deisseroth and groups led by Christopher Moore and Li-Huei Tsai at the Massachusetts Institute of Technology.

These reports are only two of a number of recent papers employing this technique to, variously, drive intracellular signaling (Airan et al., 2009); probe synaptic function (Toni et al., 2008; Liewald et al., 2008) prompt behavioral conditioning via rodent dopamine neurons (Tsai et al., 2009); and deconstruct parkinsonian circuitry (Gradinaru et al., 2009). Optogenetics have even been deployed in a non-human primate model (Han et al., 2009).—Hakon Heimer.

References:

Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and γ rhythms enhance cortical circuit performance. Nature. 2009 Apr 26. Abstract

Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces γ rhythm and controls sensory responses. Nature. 2009 Apr 26. Abstract

 
Comments on News and Primary Papers
Comment by:  Guillermo Gonzalez-Burgos
Submitted 24 July 2009 Posted 24 July 2009

Blue light, yellow light, and the role of...  Read more


View all comments by Guillermo Gonzalez-Burgos
Submit a Comment on this News Article
Make a comment on this news article. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend the Primary Papers

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


SRF News
SRF Comments
Text Size
Reset Text Size
Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright