5 June 2008. More evidence can be added to the file of schizophrenia gene suspect AKT1, according to a new paper by Daniel Weinberger’s group at the U.S. National Institute of Mental Health in Bethesda, Maryland. In their paper, published online May 22 in the Journal of Clinical Investigation, first author Hao-Yang Tan and colleagues employed a multipronged approach (see SRF related news story) to find that a functionally relevant—and schizophrenia-linked—coding variant in the AKT1 gene affects cognition and frontal cortical-striatal structures and signaling, specifically related to dopaminergic neurotransmission (see SRF related news story).
For more details, we are pleased to refer you to the open-access article, as well as a very lucid commentary by Alexander Arquello and Joseph Gogos of Columbia University in New York City.—Hakon Heimer.
Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R, Kolachana BS, Straub RE, Meyer-Lindenberg A, Sei Y, Mattay VS, Callicott JH, Weinberger DR.
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest. 2008 May 22. [Epub ahead of print]
Arguello PA, Gogos JA. A signaling pathway AKTing up in schizophrenia.
J Clin Invest. 2008 May 22. [Epub ahead of print]