26 January 2006. In the December issue of the journal Psychiatric Services, Mark Ragins, of Village Integrated Services Agency in Long Beach, California, wrote an editorial on the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) report in the September 19, 2005, issue of the New England Journal of Medicine (see SRF related news story and commentary). He suggested that the high drug discontinuation rates reflected problems with the treatment the patients received while in the study, and concluded, "I don't think the CATIE study should be a wake-up call to 'clinicians, patients, families, and policymakers.' I think it should be a wake-up call to researchers." In the January issue of Psychiatric Services, study authors Jeff Lieberman of Columbia University and John Hsiao of the National Institute of Mental Health respond to Ragins's letter, explaining aspects of the study protocol and conclusions, and pointing out that the New England Journal of Medicine report "is but an initial installment from a remarkably rich data set." (See, e.g., Goff et al., 2005; Miller et al., 2005; McEvoy et al., 2005; and Meyer et al., 2005). Access to both of these articles in Psychiatric Services is free.—Hakon Heimer.
Ragins M. Should the CATIE study be a wake-up call? Psychiatr Serv. 2005 Dec 1;56(12):1489. Abstract
Lieberman JA, Hsiao JK. Interpreting the Results of the CATIE Study. Psychiatr Serv. 2006 Jan 1;57(1):139. Abstract