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News Update: What Does CATIE Mean for Treatment?

26 January 2006. In the December issue of the journal Psychiatric Services, Mark Ragins, of Village Integrated Services Agency in Long Beach, California, wrote an editorial on the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) report in the September 19, 2005, issue of the New England Journal of Medicine (see SRF related news story and commentary). He suggested that the high drug discontinuation rates reflected problems with the treatment the patients received while in the study, and concluded, "I don't think the CATIE study should be a wake-up call to 'clinicians, patients, families, and policymakers.' I think it should be a wake-up call to researchers." In the January issue of Psychiatric Services, study authors Jeff Lieberman of Columbia University and John Hsiao of the National Institute of Mental Health respond to Ragins's letter, explaining aspects of the study protocol and conclusions, and pointing out that the New England Journal of Medicine report "is but an initial installment from a remarkably rich data set." (See, e.g., Goff et al., 2005; Miller et al., 2005; McEvoy et al., 2005; and Meyer et al., 2005). Access to both of these articles in Psychiatric Services is free.—Hakon Heimer.

References:
Ragins M. Should the CATIE study be a wake-up call? Psychiatr Serv. 2005 Dec 1;56(12):1489. Abstract

Lieberman JA, Hsiao JK. Interpreting the Results of the CATIE Study. Psychiatr Serv. 2006 Jan 1;57(1):139. Abstract

 
Comments on News and Primary Papers
Primary Papers: Interpreting the Results of the CATIE Study.

Comment by:  Patricia Estani
Submitted 4 February 2006 Posted 6 February 2006
  I recommend this paper

In the comment about the CATIE study, Dr. Ragins described...  Read more


View all comments by Patricia Estani

Comment by:  Marvin Herz
Submitted 7 February 2006 Posted 8 February 2006

I believe that the results of the CATIE study indirectly...  Read more


View all comments by Marvin Herz
Comments on Related Papers
Related Paper: Cure therapeutics and strategic prevention: raising the bar for mental health research.

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 17 January 2006 Posted 18 January 2006
  I recommend this paper

This perspective piece is right on target. Little progress...  Read more


View all comments by William Carpenter

Related Paper: Is quality of life among minimally symptomatic patients with schizophrenia better following withdrawal or continuation of antipsychotic treatment?

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 22 January 2006 Posted 23 January 2006
  I recommend this paper

There are a number of studies suggesting that a subgroup...  Read more


View all comments by William Carpenter

Related Paper: Cure therapeutics and strategic prevention: raising the bar for mental health research.

Comment by:  Ed Francell
Submitted 24 January 2006 Posted 25 January 2006
  I recommend this paper

This article states very well the divergent approaches...  Read more


View all comments by Ed Francell
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