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News
Jun 07 2017
Author: Joshua Roffman
Comment: One additional update: While change in negative symptoms did not correlate with change in mPFC thickness in the l-methylfolate study (n = 35), some new results from Walton, Ehrlich, and colleagues...
News
May 25 2017
Author: Maureen Martin
Comment: I wonder if response to methylfolate is associated with the presence of folate receptor autoantibodies in schizophrenia (Ramaekers et al., 2014), and if methylfolate response and folate receptor...
News
May 02 2017
Author: Peter Uhlhaas
Comment: This is a very intriguing paper that makes a number of important observations that are relevant for understanding the pathophysiology of schizophrenia. Firstly, diverse animal models converge on a...
News
May 02 2017
Author: Joseph Firth
Comment: This comment was co-written by Alison Yung. The pioneering study by Joshua Roffman and colleagues (2017) represents a positive step forward toward demonstrating and understanding the efficacy of...
News
Apr 13 2017
Author: Joshua Roffman
Comment: Thanks to Dr. Buchanan for his insightful comments, which I will do my best to address here. 1. Regarding the rationale for methylfolate versus folic acid: I appreciate the opportunity to clarify...
News
Apr 11 2017
Author: Edmund Rolls
Comment: An attractor network approach to schizophrenia, and empirical tests A computational neuroscience approach to the symptoms, mechanisms of, and treatments for schizophrenia (Loh et al., 2007; Rolls...
Biblio
Apr 10 2017
Author: Cameron Carter
Comment: This is another interesting and important set of results indicating that cortical thickness and volume changes reported in schizophrenia are related, at least in part, to the effects of antipsychotic...
News
Mar 31 2017
Author: Robert W. Buchanan
Comment: I think that the examination of the efficacy of L-methylfolate (LMF) in people with schizophrenia is a logical extension of the previous work of Roffman and colleagues with folate supplementation....
Biblio
Feb 23 2017
Author: Anissa Abi-Dargham
Comment: The study by Artiges and colleagues is intriguing: It contradicts many other studies that do not find an increase in DAT in schizophrenia, as described by the authors. In order to better evaluate the...
News
Feb 20 2017
Author: Vinay Parikh
Comment: This elegant study provides a new biological framework to treat the negative and cognitive symptoms of schizophrenia that are known to be associated with the dysfunction of the prefrontal cortex. All...