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Jul 24 2017
Author: Mark Daly
Comment: I think both play a role in each phenotype, and we need to invest more in analyses that span all types of variants. As they both have roughly 80 percent heritability, there is clearly a lot to learn...
Forums
Jul 24 2017
Author: Chao Chen
Comment: For different psychiatric diseases, should we focus more on de novo mutations/rare variants in autism and more on common variants in schizophrenia?
Forums
Jul 24 2017
Author: Francis McMahon
Comment: I was an early enthusiast for splitting based on clinical subtypes, but I think this has not been a very successful approach. When sample sizes are large enough―larger than we probably have so far...
Forums
Jul 24 2017
Author: Ellen Ovenden
Comment: How important is clinical homogeneity in GWAS? Schizophrenia has many different subtypes/symptom domains that may be controlled by different pathways. Would grouping patients by these factors alter...
Biblio
Jul 07 2017
Author: Adam Culbreth
Comment: Disparate Neural Mechanisms of Effort-Based Reinforcement-Learning in Depression and Schizophrenia This comment was co-written by Erin Moran. Motivational deficits have long been associated with...
News
Jun 07 2017
Author: Joshua Roffman
Comment: One additional update: While change in negative symptoms did not correlate with change in mPFC thickness in the l-methylfolate study (n = 35), some new results from Walton, Ehrlich, and colleagues...
News
May 25 2017
Author: Maureen Martin
Comment: I wonder if response to methylfolate is associated with the presence of folate receptor autoantibodies in schizophrenia (Ramaekers et al., 2014), and if methylfolate response and folate receptor...
News
May 02 2017
Author: Peter Uhlhaas
Comment: This is a very intriguing paper that makes a number of important observations that are relevant for understanding the pathophysiology of schizophrenia. Firstly, diverse animal models converge on a...
News
May 02 2017
Author: Joseph Firth
Comment: This comment was co-written by Alison Yung. The pioneering study by Joshua Roffman and colleagues (2017) represents a positive step forward toward demonstrating and understanding the efficacy of...
News
Apr 13 2017
Author: Joshua Roffman
Comment: Thanks to Dr. Buchanan for his insightful comments, which I will do my best to address here. 1. Regarding the rationale for methylfolate versus folic acid: I appreciate the opportunity to clarify...