Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Plain English
back to Plain English Search News Story
The Underpinnings of Psychosis Risk

September 18, 2013. What does a brain vulnerable to developing psychosis look like? A new study in JAMA Psychiatry published online September 4 finds that such at-risk brains exhibit patterns of neural activity resembling those found in psychosis, with weak connections in one place and overexuberant connections in another.

Led by Alex Fornito of Monash University in Melbourne, Australia, and colleagues at University of Cambridge, United Kingdom, the study focused on a region called the striatum, a structure located deep within the brain that some researchers think is a crossroads for psychosis. The striatum, however, is a complicated place: Part of it is connected to brain regions involved in complex thinking, and another section is connected to parts of the brain involved in emotion.

Using brain scanning, the researchers examined the state of the connections linking these other parts of the brain to the striatum. They not only scanned people newly ill with psychosis, but also their healthy parents or siblings. Because these relatives carry some of the substantial genetic factors contributing to psychosis, any unusual connections found in the relatives that overlapped with those found in people with psychosis could constitute a sign of a brain at risk for psychosis. Indeed, compared to controls, the researchers found that both groups showed a striatum that was only weakly connected to its complex-thought partners, but heavily connected to its emotion brain counterparts. (For more details, see the related news story.)—Michele Solis.

 
SRF News
SRF Comments
Text Size
Reset Text Size
Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright