Send in your comments now! The paper under discussion: Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Færden A, Jónsdóttir H, Ringen PA, Opjordsmoen S, Melle I, Friis S, Andreassen OA. Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group. Schizophr Bull. 2009 May 14. Abstract
As discussed by Dr. Moghaddam in a prior Schizophrenia Research Forum hypothesis review, glutamatergic hypotheses of schizophrenia are based upon the ability of NMDA receptor antagonists, such as phencyclidine (PCP), ketamine, or MK-801, to induce psychotic symptoms closely resembling those of schizophrenia.
The current inhabitant of the NIMH hot seat is Tom Insel. Insel is in charge of a budget in the $1.5 billion range, and while he answers officially to the executive branch, he must also mediate the unofficial demands of legislators and numerous interest groups
We held a lively discussion on September 12, 2006, led by Ofer Agid and Shitij Kapur of the University of Toronto, with Patricio O'Donnell, of the University of Maryland, Baltimore, joining us as moderator. As introduced in a series of papers over the past few years, Agid, Kapur, and their colleagues in Toronto believe that antipsychotic drugs begin to work clinically within days of treatment onset.
The paper under discussion: Tochigi M, Otowa T, Suga M, Rogers M, Minato T, Yamasue H, Kasai K, Kato N, Sasaki T. No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits. Schizophr Res. 2006 Jul 17; [Epub ahead of print]
Paternal age at conception is a robust risk factor for schizophrenia. Possible mechanisms include de novo point mutations or defective epigenetic regulation of paternal genes. The predisposing genetic events appear to occur probabilistically
The glutamate hypothesis of schizophrenia posits that the function of the N-methyl-D-aspartate (NMDA) receptor is compromised in this disease. NMDA receptors are a major subtype of glutamate receptors and mediate slow excitatory postsynaptic potentials
Robin Murray has seen patients and studied mental illness since the early 1970s, for most of that time in London. A leader in European schizophrenia research and care, Murray currently is professor of psychiatry at the Institute of Psychiatry at Maudsley Hospital