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How Might Dysbindin Affect the Schizophrenic Brain?

Posted on 4 Oct 2009

In our Forum Discussion "journal club" series, the editors of Neuropsychopharmacology provide access to the full text of a recent article.

Online Discussions

SRF Interviews Philip D. Harvey

Posted on 26 Sep 2009

For years, Philip D. Harvey has made the cognitive deficits that cause much of the disability associated with schizophrenia a focus of his research.

SRF Interviews

Neurocognitive Dysfunction in Schizophrenia and Bipolar Disorder

Posted on 10 Aug 2009

Send in your comments now! The paper under discussion:
Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Færden A, Jónsdóttir H, Ringen PA, Opjordsmoen S, Melle I, Friis S, Andreassen OA. Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group. Schizophr Bull. 2009 May 14. Abstract

Online Discussions

Is the Risk Syndrome for Psychosis Risky Business?

Posted on 21 Jul 2009

Led by William T. Carpenter Jr.
Live discussion held 22 July 2009.

Online Discussions

The Role of the Social Environment in Psychiatric Research: Outstanding Challenges and Future Directions

Posted on 16 Mar 2009

Led by Dana March, James Kirkbride, and Wim Veling.
Live discussion held 17 March 2009.

Online Discussions

DISC1 Roundtable 2009

Posted on 12 Jan 2009

Led by Akira Sawa, Nick Brandon, and Ty Cannon.
Live discussion held 13 January 2009.

Online Discussions

Glutamate From a Cortical Perspective

Posted on 23 Jul 2008

As discussed by Dr. Moghaddam in a prior Schizophrenia Research Forum hypothesis review, glutamatergic hypotheses of schizophrenia are based upon the ability of NMDA receptor antagonists, such as phencyclidine (PCP), ketamine, or MK-801, to induce psychotic symptoms closely resembling those of schizophrenia.

Current Hypotheses

New Approaches to Cognition in Mental Illness

Posted on 8 Jun 2008

Led by Fred Sabb, Bob Bilder, and Deanna Barch.
Live discussion held 9 June 2008.

Online Discussions

An Epigenetic Hypothesis for Schizophrenia Pathophysiology

Posted on 16 Jan 2008

Schizophrenia (Sz) is a devastating disorder of brain function with a population-wide morbidity approaching 1 percent.

Current Hypotheses

Gene Expression Profiling of Postmortem Human Brain

Posted on 8 Jan 2008

Led by Akira Sawa and Marquis Vawter.
Live discussion held 9 January 2008

Online Discussions

SRF Interviews Tom Insel

Posted on 8 Aug 2007

The current inhabitant of the NIMH hot seat is Tom Insel. Insel is in charge of a budget in the $1.5 billion range, and while he answers officially to the executive branch, he must also mediate the unofficial demands of legislators and numerous interest groups

SRF Interviews

The New Epidemiology of Schizophrenia

Posted on 10 Apr 2007

Led by John McGrath.
Live Discussion held 11 April 2007.

Online Discussions

Antibodies to Toxoplasma gondii in Patients with Schizophrenia: A Meta-Analysis

Posted on 21 Feb 2007

Send in your comments now! The paper under discussion:
Antibodies to Toxoplasma gondii in Patients With Schizophrenia: A Meta-Analysis.

Online Discussions

Bad Brain Vibes: Disturbances of Inhibitory Neural Circuits and Gamma Oscillations in Schizophrenia

Posted on 26 Oct 2006

In modern accounts of schizophrenia, researchers have proposed that the disorder arises from a failure to integrate the activity of local and distributed neural circuits

Current Hypotheses

Is Active Psychosis Neurotoxic?

Posted on 4 Oct 2006

The paper under discussion:
McGlashan TH. Is Active Psychosis Neurotoxic? Schizophr Bull. 2006; 32:609-613.

Online Discussions

The Lack of Delay in the "Onset" of Antipsychotic Action: Implications from the Bench to the Bedside

Posted on 11 Sep 2006

We held a lively discussion on September 12, 2006, led by Ofer Agid and Shitij Kapur of the University of Toronto, with Patricio O'Donnell, of the University of Maryland, Baltimore, joining us as moderator. As introduced in a series of papers over the past few years, Agid, Kapur, and their colleagues in Toronto believe that antipsychotic drugs begin to work clinically within days of treatment onset.

Online Discussions

Is BDNF's Star Fading in the Schizophrenia Research Universe?

Posted on 4 Aug 2006

The paper under discussion:
Tochigi M, Otowa T, Suga M, Rogers M, Minato T, Yamasue H, Kasai K, Kato N, Sasaki T. No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits. Schizophr Res. 2006 Jul 17; [Epub ahead of print]

Online Discussions

The NIMH-MATRICS Consensus Statement on Negative Symptoms"Schizophrenia Bulletin

Posted on 13 Jun 2006

The paper under discussion:
Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR. The NIMH-MATRICS Consensus Statement on Negative Symptoms.Schizophr Bull. 2006 Feb 15; [Epub ahead of print]

Online Discussions

rTMS for Schizophrenia

Posted on 1 Jun 2006
Online Discussions

New Findings in Psychosis: Breaking Down Diagnostic Barriers

Posted on 14 May 2006

Led by Nick Craddock and Mike Owen.
Live discussion held 15 May 2006.

Online Discussions

SRF Interviews David Lewis

Posted on 6 Apr 2006

SRF Interviews

Schizophrenia Risk and the Paternal Germ Line

Posted on 2 Mar 2006

Paternal age at conception is a robust risk factor for schizophrenia. Possible mechanisms include de novo point mutations or defective epigenetic regulation of paternal genes. The predisposing genetic events appear to occur probabilistically

Current Hypotheses

Identifying Phenotypes and Endophenotypes in Schizophrenia (Psychosis) Research

Posted on 9 Jan 2006

Led by Irv Gottesman and Mayada Akil.
Live discussion held 10 January 2006.

Online Discussions

Glutamate Hypothesis of Schizophrenia

Posted on 7 Nov 2005

The glutamate hypothesis of schizophrenia posits that the function of the N-methyl-D-aspartate (NMDA) receptor is compromised in this disease. NMDA receptors are a major subtype of glutamate receptors and mediate slow excitatory postsynaptic potentials

Current Hypotheses

SRF Interviews Robin Murray

Posted on 17 Oct 2005

Robin Murray has seen patients and studied mental illness since the early 1970s, for most of that time in London. A leader in European schizophrenia research and care, Murray currently is professor of psychiatry at the Institute of Psychiatry at Maudsley Hospital

SRF Interviews