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Treatment-Resistant Schizophrenia: New Guidelines on Diagnosis and Terminology

By Hakon Heimer Posted on 20 Feb 2017

ChristophCorrell OliverHowes JohnKaneHakonHeimer

February 21, Schizophrenia Research Forum held a discussion about new guidelines on treatment-resistant schizophrenia. Oliver Howes of the Institute of Psychiatry in London, and Christoph Correll and John Kane of Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, were the prime movers behind the Treatment Response and Resistance in Psychosis (TRRIP) Working Group, which published its consensus statement recently in the American Journal of Psychiatry (Howes et al., 2017).

This discussion featured the following panelists:

  • Christoph Correll, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York
  • Oliver Howes, Institute of Psychiatry, London
  • John Kane, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York
  • Hakon Heimer, Schizophrenia Research Forum, Moderator

In a series of meetings at schizophrenia conferences over the past few years, the TRRIP group has grappled with the lack of standard criteria for determining that a person is resistant to treatment with antipsychotic medications. This problem affects 1) research, where inconsistent criteria make meta-analyses difficult and produce conflicting results for medication efficacy, and 2) clinical care, where patients may not receive optimal care. The panelists will present their methodology for developing consensus guidelines and general principles of defining treatment-resistant schizophrenia, as well as their recommendations for determining and reporting treatment resistance or response.


Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJ, Birnbaum ML, Bloomfield MA, Bressan RA, Buchanan RW, Carpenter WT, Castle DJ, Citrome L, Daskalakis ZJ, Davidson M, Drake RJ, Dursun S, Ebdrup BH, Elkis H, Falkai P, Fleischacker WW, Gadelha A, Gaughran F, Glenthøj BY, Graff-Guerrero A, Hallak JE, Honer WG, Kennedy J, Kinon BJ, Lawrie SM, Lee J, Leweke FM, MacCabe JH, McNabb CB, Meltzer H, Möller HJ, Nakajima S, Pantelis C, Reis Marques T, Remington G, Rossell SL, Russell BR, Siu CO, Suzuki T, Sommer IE, Taylor D, Thomas N, Üçok A, Umbricht D, Walters JT, Kane J, Correll CU. Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology. Am J Psychiatry. 2016 Dec 6:appiajp201616050503. [Epub ahead of print] PMID: 27919182


Listen to the Webinar


Oliver Howes' Presentation


Christoph Correll's Presentation


John Kane's Presentation