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The NIMH-MATRICS Consensus Statement on Negative Symptoms"Schizophrenia Bulletin

Posted on 13 Jun 2006
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This is the first of our Forum journal discussions, in which the editors of Schizophrenia Bulletin or Schizophrenia Research will provide access to the full text of a new article. A short introduction by a journal editor, below, will get us started, and then it's up to our readers to share their ideas and insights, questions and reactions to the selected paper. So read on"



Treating Negative Symptoms in Schizophrenia
The NIMH MATRICS process has given focus to impaired cognition as an unmet therapeutic need in schizophrenia. Negative symptom pathology is seen as the next area for focus, and a workshop was held in January, 2005. A consensus statement on negative symptoms including criteria for a clinical trial design which would address pseudospecificity and meet FDA requires for an indication was developed. The workshop report and papers on the five domains of the negative symptom construct will be published in the April 2006 issue of Schizophrenia Bulletin. Articles for the negative symptom issue are available online to subscribers, and the consensus statement is available free to SRF readers.

We invite readers to contribute their experience and ideas to this discussion...

(Another way to contribute to research on negative symptoms is to offer suggestions on the working draft of a new Negative Symptom Rating Scale, being developed under the aegis of the MATRICS project.)

Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR. The NIMH-MATRICS Consensus Statement on Negative Symptoms. Schizophr Bull. 2006 Feb 15; [Epub ahead of print] Abstract