On Monday, 16 November 2009, Anthony Grace and Stephan Heckers led a live discussion.
The hippocampus has been a focus of increasing interest in the schizophrenia research community since the 1980s (Heckers and Konradi, 2002). A large literature has convincingly shown that hippocampal volume is smaller in schizophrenia patients (for review/meta-analysis, see Steen et al., 2006), as well as in their first-degree relatives (Boos et al., 2007). This is complemented by functional neuroimaging studies, which suggest that hippocampal activity is increased at baseline, but decreased during task performance (numerous studies, see PubMed results). A recent study reports that increased blood volume in the CA1 subfield of the hippocampus may predict the at-risk, or prodromal, stage of psychotic disorders (Schobel et al., 2009; see SRF related news story).