As discussed by Dr. Moghaddam in a prior Schizophrenia Research Forum hypothesis review, glutamatergic hypotheses of schizophrenia are based upon the ability of NMDA receptor antagonists, such as phencyclidine (PCP), ketamine, or MK-801, to induce psychotic symptoms closely resembling those of schizophrenia.
Paternal age at conception is a robust risk factor for schizophrenia. Possible mechanisms include de novo point mutations or defective epigenetic regulation of paternal genes. The predisposing genetic events appear to occur probabilistically
The glutamate hypothesis of schizophrenia posits that the function of the N-methyl-D-aspartate (NMDA) receptor is compromised in this disease. NMDA receptors are a major subtype of glutamate receptors and mediate slow excitatory postsynaptic potentials