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Current Hypotheses

The Dopamine Hypothesis of Schizophrenia

Posted on 3 Dec 2012

The dopamine (DA) hypothesis is the oldest and most established of the schizophrenia hypotheses.

Current Hypotheses

Glutamate From a Cortical Perspective

Posted on 23 Jul 2008

As discussed by Dr. Moghaddam in a prior Schizophrenia Research Forum hypothesis review, glutamatergic hypotheses of schizophrenia are based upon the ability of NMDA receptor antagonists, such as phencyclidine (PCP), ketamine, or MK-801, to induce psychotic symptoms closely resembling those of schizophrenia.

Current Hypotheses

An Epigenetic Hypothesis for Schizophrenia Pathophysiology

Posted on 16 Jan 2008

Schizophrenia (Sz) is a devastating disorder of brain function with a population-wide morbidity approaching 1 percent.

Current Hypotheses

Bad Brain Vibes: Disturbances of Inhibitory Neural Circuits and Gamma Oscillations in Schizophrenia

Posted on 26 Oct 2006

In modern accounts of schizophrenia, researchers have proposed that the disorder arises from a failure to integrate the activity of local and distributed neural circuits

Current Hypotheses

Schizophrenia Risk and the Paternal Germ Line

Posted on 2 Mar 2006

Paternal age at conception is a robust risk factor for schizophrenia. Possible mechanisms include de novo point mutations or defective epigenetic regulation of paternal genes. The predisposing genetic events appear to occur probabilistically

Current Hypotheses

Glutamate Hypothesis of Schizophrenia

Posted on 7 Nov 2005

The glutamate hypothesis of schizophrenia posits that the function of the N-methyl-D-aspartate (NMDA) receptor is compromised in this disease. NMDA receptors are a major subtype of glutamate receptors and mediate slow excitatory postsynaptic potentials

Current Hypotheses