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Online Discussions

Updated 16 December 2009
Printable version

Live Discussion: DISC1 Roundtable 2010

David Porteous

Akira Sawa

It has been a busy year again for the DISC1 research community, so we invite you to join us once again for a live discussion on Wednesday, 13 January 2010, from 12:00 noon to 1 p.m. (U.S. EST), led by Akira Sawa, Johns Hopkins University, and David Porteous, University of Edinburgh. DISC1 barely needs introduction or justification any longer as a suitable topic for SRF discussion.

DISC1 is now well established as what Tom Insel, Director of the U.S. National Institute of Mental Health, has termed an “edge piece” of psychiatric genetics. Many studies have reported effects of DISC1 genetic variation on a spectrum of psychiatric disorders, including and extending beyond the schizophrenia, bipolar disorder, unipolar depression, and adolescent conduct disorder reported in the original Scottish family with a balanced t(1;11) translocation through which DISC1 was identified. The neurodevelopmental and neurosignaling roles of DISC1 are increasingly well understood through the scaffold function of DISC1, including GSK3β, PCM1, PDE4, NDE1, and NDEL1, to name but some of the currently most interesting and well studied interactors that are illuminating normal and pathogenetic brain processes. (See Brandon et al., 2009; Porteous and Millar, 2009; Jaaro-Peled et al., 2009; and Chubb et al., 2008 for more background and review summaries.)

The focus of this meeting will be as follows:

1. Update on animal models: What are these models telling us about the neurobiology of DISC1? What are the key DISC1-associated behavioral phenotypes? What kinds of criteria, including histological and molecular hallmarks, are most relevant to translational research? What experiments still need to be done? What other models are needed?

2. Update on DISC1 genetics: What is the status on evidence for common risk variants and rare mutations in the DISC1 pathway? What do these tell us about genotype-phenotype relationships? What do they tell us about structure-function relationships?

3. Update on DISC1 signalosome: What underlies the temporal and spatial specificity of DISC1 pathways in brain circuitry, such as isoform disposition, post-translational modifications, and different combinations of protein interactors?

We now invite your comments in advance of the live discussion and look forward to your participation.

See also DISC1 Roundtable 2009 and The DISC1 Pathway in Major Mental Illness: Clinical, Genetic and Biological Evidence—Current Status and Future Prospects.

View Transcript of Live Discussion — Posted 4 June 2010

View Comments By:
Mikhail Pletnikov — Posted 12 January 2010
Atsushi Kamiya — Posted 12 January 2010
Bernard Crespi — Posted 12 January 2010
Tatiana Lipina — Posted 12 January 2010
David St Clair — Posted 12 January 2010
Chris Carter — Posted 22 June 2010

Comments on Online Discussion
Comment by:  Mikhail Pletnikov
Submitted 12 January 2010 Posted 12 January 2010

To follow up on Atsushi's and Tatiana's comments, I would...  Read more

View all comments by Mikhail Pletnikov

Comment by:  Atsushi Kamiya
Submitted 11 January 2010 Posted 12 January 2010

Accumulating evidence suggests that DISC1 plays roles in...  Read more

View all comments by Atsushi Kamiya

Comment by:  Bernard Crespi
Submitted 12 January 2010 Posted 12 January 2010

A recent study (  Read more

View all comments by Bernard Crespi

Comment by:  Tatiana Lipina
Submitted 12 January 2010 Posted 12 January 2010

Response to: 1. Update on animal models: What are these...  Read more

View all comments by Tatiana Lipina

Comment by:  David St Clair
Submitted 12 January 2010 Posted 12 January 2010

I am currently at NIMH as visiting scientist. Barbara...  Read more

View all comments by David St Clair

Comment by:  Chris Carter
Submitted 20 June 2010 Posted 22 June 2010

DISC1 is clearly hugely important, acting as a "hub gene"...  Read more

View all comments by Chris Carter
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