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Online Discussions

Updated 18 January 2010 E-mail discussion
Printable version

Live Discussion: Hippocampus in Schizophrenia Roundtable


Anthony Grace

Stephan Heckers

On Monday, 16 November 2009, Anthony Grace and Stephan Heckers led a live discussion.

The hippocampus has been a focus of increasing interest in the schizophrenia research community since the 1980s (Heckers and Konradi, 2002). A large literature has convincingly shown that hippocampal volume is smaller in schizophrenia patients (for review/meta-analysis, see Steen et al., 2006), as well as in their first-degree relatives (Boos et al., 2007). This is complemented by functional neuroimaging studies, which suggest that hippocampal activity is increased at baseline, but decreased during task performance (numerous studies, see PubMed results). A recent study reports that increased blood volume in the CA1 subfield of the hippocampus may predict the at-risk, or prodromal, stage of psychotic disorders (Schobel et al., 2009; see SRF related news story).

A much-discussed synthesis of hippocampal pathology in schizophrenia, which grew out of a 2007 Society for Neuroscience symposium, also gives the hippocampus a central role (Lisman et al., 2008; see also SRF related related meeting report). One hypothesis in this suite of models is that decreased hippocampal GABA signaling in schizophrenia disinhibits the outputs from the structure, leading to an overactive dopamine system (Lodge et al., 2009; see SRF related meeting report and slidecast by A.A. Grace), while another posits that the hippocampal GABA deficiency can be traced to faulty input from the basolateral amygdala (Berretta et al., 2009; see SRF related news story).

This discussion was exploratory, so we rely on our readers' comments to bring up the findings you find most compelling from your own and others’ research.

View Transcript of Live Discussion — Posted 18 January 2010

View Comments By:
Tobias Bast — Posted 2 November 2009
Stephan Heckers — Posted 3 November 2009
Inna Gaisler-Salomon — Posted 15 November 2009
Anthony Grace — Posted 16 November 2009
Melanie Foecking, David Cotter — Posted 16 November 2009
Paul Harrison — Posted 18 November 2009
Segundo Mesa-Castillo — Posted 23 November 2009



Comments on Online Discussion
Comment by:  Tobias Bast
Submitted 2 November 2009 Posted 2 November 2009

Perhaps the issue of functional differentiation along the...  Read more


View all comments by Tobias Bast

Comment by:  Stephan Heckers, SRF Advisor
Submitted 3 November 2009 Posted 3 November 2009

This is a very good suggestion. We will review the...  Read more


View all comments by Stephan Heckers

Comment by:  Inna Gaisler-Salomon
Submitted 15 November 2009 Posted 15 November 2009

As correctly pointed out by Tobias Bast, the hippocampus...  Read more


View all comments by Inna Gaisler-Salomon

Comment by:  Anthony Grace, SRF Advisor (Disclosure)
Submitted 16 November 2009 Posted 16 November 2009

Actually, these are all good points. But as with most...  Read more


View all comments by Anthony Grace

Comment by:  Melanie FoeckingDavid Cotter
Submitted 16 November 2009 Posted 16 November 2009

In addition to the really interesting findings in CA1, I...  Read more


View all comments by Melanie Foecking
View all comments by David Cotter

Comment by:  Paul Harrison
Submitted 18 November 2009 Posted 18 November 2009

Sorry I missed the discussion, and I look forward to...  Read more


View all comments by Paul Harrison

Comment by:  Segundo Mesa-Castillo
Submitted 23 November 2009 Posted 23 November 2009

Use of new imaging technology has enabled researchers to...  Read more


View all comments by Segundo Mesa-Castillo
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