Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Online Discussions

Updated 18 January 2010
Printable version

Live Discussion: Hippocampus in Schizophrenia Roundtable

Anthony Grace

Stephan Heckers

On Monday, 16 November 2009, Anthony Grace and Stephan Heckers led a live discussion.

The hippocampus has been a focus of increasing interest in the schizophrenia research community since the 1980s (Heckers and Konradi, 2002). A large literature has convincingly shown that hippocampal volume is smaller in schizophrenia patients (for review/meta-analysis, see Steen et al., 2006), as well as in their first-degree relatives (Boos et al., 2007). This is complemented by functional neuroimaging studies, which suggest that hippocampal activity is increased at baseline, but decreased during task performance (numerous studies, see PubMed results). A recent study reports that increased blood volume in the CA1 subfield of the hippocampus may predict the at-risk, or prodromal, stage of psychotic disorders (Schobel et al., 2009; see SRF related news story).

A much-discussed synthesis of hippocampal pathology in schizophrenia, which grew out of a 2007 Society for Neuroscience symposium, also gives the hippocampus a central role (Lisman et al., 2008; see also SRF related related meeting report). One hypothesis in this suite of models is that decreased hippocampal GABA signaling in schizophrenia disinhibits the outputs from the structure, leading to an overactive dopamine system (Lodge et al., 2009; see SRF related meeting report and slidecast by A.A. Grace), while another posits that the hippocampal GABA deficiency can be traced to faulty input from the basolateral amygdala (Berretta et al., 2009; see SRF related news story).

This discussion was exploratory, so we rely on our readers' comments to bring up the findings you find most compelling from your own and others’ research.

View Transcript of Live Discussion — Posted 18 January 2010

View Comments By:
Tobias Bast — Posted 2 November 2009
Stephan Heckers — Posted 3 November 2009
Inna Gaisler-Salomon — Posted 15 November 2009
Anthony Grace — Posted 16 November 2009
Melanie Foecking, David Cotter — Posted 16 November 2009
Paul Harrison — Posted 18 November 2009
Segundo Mesa-Castillo — Posted 23 November 2009

Comments on Online Discussion
Comment by:  Tobias Bast
Submitted 2 November 2009 Posted 2 November 2009

Perhaps the issue of functional differentiation along the...  Read more

View all comments by Tobias Bast

Comment by:  Stephan Heckers, SRF Advisor
Submitted 3 November 2009 Posted 3 November 2009

This is a very good suggestion. We will review the...  Read more

View all comments by Stephan Heckers

Comment by:  Inna Gaisler-Salomon
Submitted 15 November 2009 Posted 15 November 2009

As correctly pointed out by Tobias Bast, the hippocampus...  Read more

View all comments by Inna Gaisler-Salomon

Comment by:  Anthony Grace, SRF Advisor (Disclosure)
Submitted 16 November 2009 Posted 16 November 2009

Actually, these are all good points. But as with most...  Read more

View all comments by Anthony Grace

Comment by:  Melanie FoeckingDavid Cotter
Submitted 16 November 2009 Posted 16 November 2009

In addition to the really interesting findings in CA1, I...  Read more

View all comments by Melanie Foecking
View all comments by David Cotter

Comment by:  Paul Harrison
Submitted 18 November 2009 Posted 18 November 2009

Sorry I missed the discussion, and I look forward to...  Read more

View all comments by Paul Harrison

Comment by:  Segundo Mesa-Castillo
Submitted 23 November 2009 Posted 23 November 2009

Use of new imaging technology has enabled researchers to...  Read more

View all comments by Segundo Mesa-Castillo
Submit a Comment on This Online Discussion
Make a comment on this live discussion. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Live Discussion FAQs

Webinar: A Webinar is a seminar conducted remotely over the Web. Attendees view the slides through their Web browser and hear the presentations over their own telephones.

Registration: All participants are to register by clicking on the "Register for the Webinar" link.

Access: After you register, you will receive an e-mail with a link to the Webinar and a phone number.
New Schizophrenia Fact Sheet for Patients and Families

Latest BBRF Research Breakthroughs

Visit our Facebook page and our Blog.

Support the Brain & Behavior Research Foundation Today.

Research Participants
Copyright © 2005- 2016 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright