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Updated 13 March 2006 E-mail discussion
Printable version

Forum Discussion: The NIMH-MATRICS Consensus Statement on Negative Symptoms—Schizophrenia Bulletin

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This is the first of our Forum journal discussions, in which the editors of Schizophrenia Bulletin or Schizophrenia Research will provide access to the full text of a new article. A short introduction by a journal editor, below, will get us started, and then it's up to our readers to share their ideas and insights, questions and reactions to the selected paper. So read on…

View Comments By:
Patricia Estani — Posted 27 March 2006
Philip Harvey — Posted 12 April 2006
William Carpenter — Posted 23 April 2006
Kiumars Lalezarzadeh — Posted 25 May 2006

Treating Negative Symptoms in Schizophrenia
The NIMH MATRICS process has given focus to impaired cognition as an unmet therapeutic need in schizophrenia. Negative symptom pathology is seen as the next area for focus, and a workshop was held in January, 2005. A consensus statement on negative symptoms including criteria for a clinical trial design which would address pseudospecificity and meet FDA requires for an indication was developed. The workshop report and papers on the five domains of the negative symptom construct will be published in the April 2006 issue of Schizophrenia Bulletin. Articles for the negative symptom issue are available online to subscribers, and the consensus statement is available free to SRF readers.

We invite readers to contribute their experience and ideas to this discussion...

(Another way to contribute to research on negative symptoms is to offer suggestions on the working draft of a new Negative Symptom Rating Scale, being developed under the aegis of the MATRICS project.)

Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR. The NIMH-MATRICS Consensus Statement on Negative Symptoms. Schizophr Bull. 2006 Feb 15; [Epub ahead of print] Abstract

Comments on Online Discussion
Comment by:  Patricia Estani
Submitted 23 March 2006 Posted 27 March 2006

The NIMH-MATRICS consensus statement on negative symptoms is an excellent article. I think that this kind of consensus is needed in the field of behavioral research, and specifically in the field of schizophrenia research. We know a lot about the positive symptoms of the disease, but the weakest points of research in schizophrenia are the negative symptoms and the cognitive impairments of the pathology. This need for consensus is necessary not only at a clinical level, but also at a behavioral research level.

Thus, this consensus must be developed, and it will be a point of more discussion. The psychopharmacology is one of the most outstanding aspects of the discussion. At a first look, the psychopharmacology has failed by focusing its attention on reducing positive symptoms. In the discrimination of negative symptoms, sometimes it is difficult to separate primary from secondary negative symptoms, and I think that this distinction is needed. I think that a consensus about negative symptoms has just started and a lot of work is needed.


Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR. The NIMH-MATRICS Consensus Statement on Negative Symptoms. Schizophr Bull. 2006 Apr;32(2):214-9. Epub 2006 Feb 15. No abstract available. Abstract

View all comments by Patricia Estani

Comment by:  Philip Harvey
Submitted 12 April 2006 Posted 12 April 2006

The development of a consensus statement on the treatment of negative symptoms in schizophrenia is an extremely positive development. Negative symptoms represent a fundamental feature of schizophrenia and have been very poorly treated in the past. While I was a member of the consensus panel and contributed a paper to the special issue, I was not an author of the consensus statement. Thus, I am commenting on the strengths of the consensus statements and on some of the intrinsic challenges of treatment development for negative symptoms.

This consensus statement clearly attempts to delineate between negative symptoms and other features of the illness. While negative symptoms were historically delineated quite clearly from positive symptoms, various definitions of negative symptoms manifested considerable overlap with other features of the illness such as cognitive symptoms and deficits in the performance of everyday living skills. Such a delineation is critical, because it is clear that impairments in performance on cognitive tests are not markedly...  Read more

View all comments by Philip Harvey

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 22 April 2006 Posted 23 April 2006

Phil Harvey's comments are excellent. I do not share his pessimism for animal models of negative symptoms, however. Models of anhedonia were developed years ago by Roy Wise—worrisomely, a neuroleptic induced model (Wise et al., 1978). Social drive/affiliation can be modeled. Motivation models may be relevant, and animal models of empathy may also be of interest.

View all comments by William Carpenter

Comment by:  Kiumars Lalezarzadeh
Submitted 25 May 2006 Posted 25 May 2006

The consensus statement for the treatment of negative symptoms in schizophrenia is excellent. In a recent study, quantitative proton magnetic resonance spectroscopy was used to measure metabolic changes in the frontal lobe (Tanaka et al., 2006). A reduction of N-acetylaspartate in the left frontal lobe was shown to be related to negative symptoms and card sorting cognitive dysfunction in schizophrenia. The implication of this finding is that one might treat the negative symptoms by using tasks which stimulate the left frontal lobe and N-acetylaspartate.


Tanaka Y, Obata T, Sassa T, Yoshitome E, Asai Y, Ikehira H, Suhara T, Okubo Y, Nishikawa T. Quantitative magnetic resonance spectroscopy of schizophrenia: Relationship between decreased N-acetylaspartate and frontal lobe dysfunction. Psychiatry and Clinical Neurosciences. 2006;60(3):365-372.

View all comments by Kiumars Lalezarzadeh

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