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Updated 13 March 2006
Printable version

Forum Discussion: The NIMH-MATRICS Consensus Statement on Negative Symptoms—Schizophrenia Bulletin

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This is the first of our Forum journal discussions, in which the editors of Schizophrenia Bulletin or Schizophrenia Research will provide access to the full text of a new article. A short introduction by a journal editor, below, will get us started, and then it's up to our readers to share their ideas and insights, questions and reactions to the selected paper. So read on…

View Comments By:
Patricia Estani — Posted 27 March 2006
Philip Harvey — Posted 12 April 2006
William Carpenter — Posted 23 April 2006
Kiumars Lalezarzadeh — Posted 25 May 2006

Treating Negative Symptoms in Schizophrenia
The NIMH MATRICS process has given focus to impaired cognition as an unmet therapeutic need in schizophrenia. Negative symptom pathology is seen as the next area for focus, and a workshop was held in January, 2005. A consensus statement on negative symptoms including criteria for a clinical trial design which would address pseudospecificity and meet FDA requires for an indication was developed. The workshop report and papers on the five domains of the negative symptom construct will be published in the April 2006 issue of Schizophrenia Bulletin. Articles for the negative symptom issue are available online to subscribers, and the consensus statement is available free to SRF readers.

We invite readers to contribute their experience and ideas to this discussion...

(Another way to contribute to research on negative symptoms is to offer suggestions on the working draft of a new Negative Symptom Rating Scale, being developed under the aegis of the MATRICS project.)

Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR. The NIMH-MATRICS Consensus Statement on Negative Symptoms. Schizophr Bull. 2006 Feb 15; [Epub ahead of print] Abstract

Comments on Online Discussion
Comment by:  Patricia Estani
Submitted 23 March 2006 Posted 27 March 2006

The NIMH-MATRICS consensus statement on negative symptoms...  Read more

View all comments by Patricia Estani

Comment by:  Philip Harvey
Submitted 12 April 2006 Posted 12 April 2006

The development of a consensus statement on the treatment...  Read more

View all comments by Philip Harvey

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 22 April 2006 Posted 23 April 2006

Phil Harvey's comments are excellent. I do not share his...  Read more

View all comments by William Carpenter

Comment by:  Kiumars Lalezarzadeh
Submitted 25 May 2006 Posted 25 May 2006

The consensus statement for the treatment of negative...  Read more

View all comments by Kiumars Lalezarzadeh
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