Components of the Disease Process of Schizophrenia
The cluster of clinical signs and symptoms (clinical syndrome) characteristic of a brain disorder such as schizophrenia is the result of some cause or set of causes (etiology). The cause or causes induce the disease mechanisms (pathogenesis), which produce abnormalities in the brain (pathological entity) that alter its function (pathophysiology). The development of effective treatments or preventative measures requires the ability to interrupt or reverse the pathophysiological processes and pathogenetic mechanisms, respectively. For each component of the disease process of schizophrenia, the data reviewed in this article provide convergent evidence for the indicated abnormalities. TrkB, tyrosine kinase Trk (tropomyosin-related kinase) receptor B. [Image from Lewis et al., 2005. Courtesy of David Lewis and Nature Reviews Neuroscience.]