Comment by Philip Seeman—27 December 2012
In addition to the points raised in the excellent review by Anissa Abi-Dargham, it should be noted that the postsynaptic dopamine supersensitivity found in schizophrenia patients by Thompson et al. (Thompson et al., 2012) may be readily explained by the consistent increase in dopamine D2(high) receptors in all animal models of psychotic-like dopamine-supersensitive behavior (Seeman, 2010).
By the way, the discovery of the antipsychotic/dopamine D2 receptor was reported in Seeman et al. (Seeman et al., 1975) and not in Seeman and Lee (Seeman and Lee, 1975), as mentioned in this review.
Seeman P, Chau-Wong M, Tedesco J, Wong K. (1975) Brain receptors for antipsychotic drugs and dopamine: Direct binding assays. Proc Nat Acad Sci USA 72:4376-80. Abstract
Seeman P, Lee T. (1975) Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurones. Science 188:1217-9. Abstract
Seeman P. (2010) All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neuroscience and therapeutics 17(2):118-32. Abstract
Thompson JL, Urban N, Slifstein M, Xu X, Kegeles LS, Girgis RR, Beckerman Y, Harkavy-Friedman JM, Gil R, Abi-Dargham A. (2012) Striatal dopamine release in schizophrenia comorbid with substance dependence. Mol Psychiatry Aug 7. Abstract