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Schizophrenia Research Forum: Researcher Profile - Konasale Prasad
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Researcher Profile - Konasale Prasad

First Name:Konasale
Last Name:Prasad
Advanced Degrees:MD
Affiliation:University of Pittsburgh School of Medicine
Zip/Postal Code:15213
Email Address:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 19 October 2005]
Clinical Interests:
Neurodevelopmental disorders (e.g., 22q11 deletion syndromes), Bipolar disorder , Schizophrenia
Research Focus:
Brain imaging, Neurodevelopment, Clinical trials, Genetics
Work Sector(s):
Medical hospital, University
Reasearcher Bio
Dr. Prasad received his medical training in Bellary (India) and his psychiatric training at the National Institute of Mental Health and Neurosciences, Bangalore, India, Oxford Deanery and Region (UK) and at the University of Pittsburgh School of Medicine. He completed his NIMH-funded Research Fellowship at the Univ of Pittsburgh School of Medicine and is currently on the faculty of Western Psychiatric Institute and Clinic, Pittsburgh, PA.

Dr. Prasad Works with Drs. Nimgaonkar, Keshavan and Pettegrew, and is closely involved in research on the neurobiology and genetics of schizophrenia and in studying persons at an elevated risk for developing psychotic disorders. He is using a convergent approach of neuroimaging and molecular genetics to elucidate the underlying neurobiological differences. His research is supported by an NIMH Career Development Award, and a Young Investigator Award of the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD). He has received several awards including the NIMH Outstanding Resident Award and Young Investigator awards of the Indian Psychiatric Society, the World Psychiatric Association and the International Congress of Schizophrenia Research. He has published more than twenty papers in peer-reviewed papers and six book chapters.

He works as an attending psychiatrist at the Services for Treatment of Early Psychoses (STEP) and serves as the Medical Director of the ESSENCE clinic (Early Schizophrenia Support Education and Neurocognitive Enhancement) at the Western Psychiatric Institute and Clinic.
Top Papers
1: Prasad KM, Chowdari KV, Nimgaonkar VL, Talkowski ME, Lewis DA, Keshavan MS. Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients. Mol Psychiatry. 2005 Feb;10(2):213-9.
PMID: 15381923 [PubMed - indexed for MEDLINE]
2: Prasad KM, Patel AR, Muddasani S, Sweeney J, Keshavan MS. The entorhinal cortex in first-episode psychotic disorders: a structural magnetic resonance imaging study. Am J Psychiatry. 2004 Sep;161(9):1612-9.
PMID: 15337651 [PubMed - indexed for MEDLINE]
3: Prasad KM, Rohm BR, Keshavan MS. Parahippocampal gyrus in first episode psychotic disorders: a structural magnetic resonance imaging study. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):651-8.
PMID: 15276690 [PubMed - indexed for MEDLINE]
4: Diwadkar VA, Prasad KM, Keshavan MS. Approaches for adolescents with an affected family member with schizophrenia. Curr Psychiatry Rep. 2004 Aug;6(4):296-302. Review.
PMID: 15260946 [PubMed - indexed for MEDLINE]
5: Shad MU, Muddasani S, Prasad K, Sweeney JA, Keshavan MS. Insight and prefrontal cortex in first-episode Schizophrenia. Neuroimage. 2004 Jul;22(3):1315-20. PMID: 15219603 [PubMed - indexed for MEDLINE]
What are the top three papers (not yours) you have read recently?
1. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005 Jan;10(1):40-68; image 5. Review. Erratum in: Mol Psychiatry. 2005 Apr;10(4):420. Mol Psychiatry. 2005 Aug;10(8):804. PMID: 15263907 [PubMed - indexed for MEDLINE]

2. Cannon TD, van Erp TG, Bearden CE, Loewy R, Thompson P, Toga AW, Huttunen MO, Keshavan MS, Seidman LJ, Tsuang MT. Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions.
Schizophr Bull. 2003;29(4):653-69. Review.
PMID: 14989405 [PubMed - indexed for MEDLINE]

3. Stork C, Renshaw PF. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research.
Mol Psychiatry. 2005 Oct;10(10):900-19.
PMID: 16027739 [PubMed - in process]
If resources were not limited, what research projects would you pursue?
Biology of genome
What is your leading hypothesis?
Neurodevelopmental hypothesis
What piece of missing evidence would help prove it?
Disease process, evolution of the disease and the phenotypic heterogeneity

Research Participants
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