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Schizophrenia Research Forum: Researcher Profile - Steven Bakker
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Researcher Profile - Steven Bakker

First Name:Steven
Last Name:Bakker
Advanced Degrees:MD, PhD.
Affiliation:Rudolf Magnus Institute of Neuroscience
Street Address 1:University Medical Center Utrecht
Street Address 2:Heidelberglaan 100
Zip/Postal Code:3508 GA
Email Address:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 29 December 2006]
Clinical Interests:
Research Focus:
Molecular and Cell biology, Genetics
Work Sector(s):
University, Medical hospital
Web Sites:
Reasearcher Bio
1999: start PhD project in molecular genetics of schizophrenia and ADHD (Departments of Psychiatry and Biomedical Genenics, University Medical Center Utrecht, The Netherlands). Supervisors: professor R.S. Kahn, professor P.L. Pearson and professor J.K. Buitelaar

2004: start clinical training in Psychiatry at the UMC Utrecht.

2005 PhD

2005-2006: 6 months research at the Institute of Psychiatry, London (determining heritability of psychotic symptoms)
Top Papers
1: Ogdie MN, Bakker SC, Fisher SE, Francks C, Yang MH, Cantor RM, Loo SK, van
der Meulen E, Pearson P, Buitelaar J, Monaco A, Nelson SF, Sinke RJ, Smalley SL.
Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity
and a common risk locus at 5p13.
Mol Psychiatry. 2005 Oct 4; [Epub ahead of print]
PMID: 16205734

2: van der Meulen EM, Bakker SC, Pauls DL, Oteman N, Kruitwagen CL, Pearson PL,
Sinke RJ, Buitelaar JK.
High sibling correlation on methylphenidate response but no association with
DAT1-10R homozygosity in Dutch sibpairs with ADHD.
J Child Psychol Psychiatry. 2005 Oct;46(10):1074-80.
PMID: 16178931

3: de Krom M, Bakker SC, Hendriks J, van Elburg A, Hoogendoorn M, Verduijn W,
Sinke R, Kahn R, Adan RA.
Polymorphisms in the brain-derived neurotrophic factor gene are not associated
with either anorexia nervosa or schizophrenia in Dutch patients.
Psychiatr Genet. 2005 Jun;15(2):81.
PMID: 15900221

4: Hoogendoorn ML, Bakker SC, Schnack HG, Selten JP, Otten HG, Verduijn W, van
der Heijden FM, Pearson PL, Kahn RS, Sinke RJ.
No association between 12 dopaminergic genes and schizophrenia in a large Dutch
Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):6-9.
PMID: 15635698

5: Bakker SC, van der Meulen EM, Oteman N, Schelleman H, Pearson PL, Buitelaar
JK, Sinke RJ.
DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch
Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132(1):50-2.
PMID: 15389755

6: Schnack HG, Bakker SC, van 't Slot R, Groot BM, Sinke RJ, Kahn RS, Pearson
Accurate determination of microsatellite allele frequencies in pooled DNA
Eur J Hum Genet. 2004 Nov;12(11):925-34.
PMID: 15305176

7: Bakker SC, Hoogendoorn ML, Selten JP, Verduijn W, Pearson PL, Sinke RJ, Kahn
Neuregulin 1: genetic support for schizophrenia subtypes.
Mol Psychiatry. 2004 Dec;9(12):1061-3.
PMID: 15303101

8: Bakker SC, van der Meulen EM, Buitelaar JK, Sandkuijl LA, Pauls DL, Monsuur
AJ, van 't Slot R, Minderaa RB, Gunning WB, Pearson PL, Sinke RJ.
A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity
disorder: suggestive evidence for linkage on chromosomes 7p and 15q.
Am J Hum Genet. 2003 May;72(5):1251-60. Epub 2003 Apr 4.
PMID: 12679898
If resources were not limited, what research projects would you pursue?
Careful clinical phenotyping of 100,000 psychiatric patients, sequencing their entire genome, and identifying DNA variations that are associated with specific symptoms.
What is your leading hypothesis?
Psychotic symptoms are caused by an insufficient 'bandwidth' of communication between cortical areas, leading to disturbed integration of information under demanding circumstances.
Causes can be entirely different for individual patients, but they have a clear physical basis, which is largely genetically determined.
What piece of missing evidence would help prove it?
There will probably be no single piece of evidence...

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