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Schizophrenia Research Forum: Researcher Profile - Ann Olincy
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Researcher Profile - Ann Olincy

First Name:Ann
Last Name:Olincy
Title:Associate Professor of Psychiatry
Advanced Degrees:M.D., M.P.H.
Affiliation:University of Colorado Health Sciences Center
Street Address 1:4200 E 9th Avenue, Box C268-71
Zip/Postal Code:80262
Phone:303 315-5046
Fax:303 315-5347
Email Address:
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View all comments by Ann Olincy
Clinical Interests:
Anxiety disorders , Drug abuse, Attention-deficit hyperactivity disorder (ADHD, ADD) , Bipolar disorder , Schizophrenia, Borderline personality disorder, Depression
Research Focus:
Chemistry/pharmacology, Drug screening, Phenomenology/diagnosis, Electrophysiology, Epidemiology, Genetics, Clinical trials, Neurotransmission, Pharamacology
Work Sector(s):
Web Sites:
Reasearcher Bio
Dr. Ann Olincy completed her undergraduate degree in Biology at Brandeis University in Waltham, Massachusetts. She then completed a Masters Degree in Public Health, Epidemiology, at U.C.L.A. School of Public Health before attending Mayo Medical School in Rochester, Minnesota. She finished her internship and residency at University of Colorado Health Sciences Center. During her residency at UCHSC, Dr. Olincy was nominated for an NIMH Outstanding Resident Award in 1992 and received the Laughlin Fellow Award in 1994. Dr. Olincy went from her residency to a research fellowship at the Denver VA Medical Center.

Dr. Olincy then joined the faculty of UCHSC as an Instructor for the Department of Psychiatry, and last year, became an Associate Professor, a position that she still holds currently. During her tenure with UCHSC, Dr. Olincy has been the course director of the introductory psychopharmacology lecture series. She was recognized for her teaching by receiving the Jay Tully Teacher of the Year Aware in 1998 and the Eleanor Steele teaching award in 2002. In addition, Dr. Olincy currently serves as a member of Colorado Multiple Institutional Review Board (COMIRB) and a member of the University of Colorado Faculty Senate.

Dr. Olincy is also active in the mental health community, serving as the Vice President of the Board for National Alliance for the Mentally Ill, Colorado (NAMI-CO) and was honored with the Annual Exemplary Psychiatrist Award in 2000 from NAMI.
Dr. Olincy continues to do research on schizophrenia, including the role of nicotine and the genetics of this disorder, with over 30 publications in the field.
Top Papers
Adler LE, Olincy A, Cawthra E, Amass L, Freedman, R. Reversal of Diminished Inhibitory Sensory Gating in Cocaine Addicts by a Nicotinic Cholinergic Mechanism. Neuropsychopharmacolgy. 24:671-679, 2001.

Ross RG, Olincy A, Radant A. Which Duration of Post-Saccadic Slowing Identifies Anticipatory Saccades During Smooth Pursuit Eye Movements? Psychophysiology, 38:325-333, 2001.

Kisley MA, Olincy A, Freedman R. The Effect of State on Sensory Gating: Comparison of Waking, REM and non-REM Sleep. Clinical Neurophysiology, 112, 1154-1165, 2001.

Freedman R, Leonard S, Olincy A, Kauffman CA, Malaspina D, Cloninger CR, Svrakic D, Faraone SV, Tsuang MT.. Evidence for the Multigenic Inheritance of Schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics) 105:794-800, 2001.

Olincy A, Ross RG. Differential Effects of Cigarette Smoking on Performance of a Smooth Pursuit and a Saccadic Eye Movement Task in Schizophrenia. Psychiatric Research, (In revision).

Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input Dysfunction, Schizotypy, and Genetic Models of Schizophrenia. Schizophrenia Research. 54:25-32, 2002.
Publications: Olincy A, Ross RG, Freedman R. The Effects of Aging in Schizophrenia on an Antisaccade Eye Movement Task. (In submission).

Freedman R, Sirota P, Sirota L, Orr-Urterger A, Zeuerin RL, Mosheva T, Olincy A, Litwenjuk U, Adler LE, Payne R, Leonard S. Co-expression Marfan Syndrome and Schizophrenia - A Chromosomal Re-interpretation of the Madness of King Saul. (In submission).

Ross RG, Olincy A, Mikulich SK, Radant AD, Harris JG, Waldo M, Compagnon N, Heinlein S, Leonard S, Zerbe GO, Adler L, Freedman R. Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology (in press).

Leonard S, Adler LE, Benhammou K, Berger R, Breese CR, Drebing C, Gault J, Lee MJ, Logel J,, Olincy A, Ross RG, Stevens K, Sullivan B, Vianzon R, Virnich DE, Waldo M, Freedman R. Smoking and Mental Illness. (In submission, Pharmacology, Biochemistry and Behavior)

Gault J, Hopkins J, Berger R, Drebing C, Logel J, Walton K, Short M, Vianson R, Olincy A, Ross RG, Adler LE, Freedman R, Leonard S. Comparison of Polymorphism in the 7 Nicotinic Receptor Gene Cluster in Schizophrenic and Control Subjects. (In press).

Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Pinkas S, Zerbe G, Olincy a, Ross RG, Adler LE, Freedman R. Promoter Variants in the 7 Nicotinic Acetylcholine Receptor Subunit Gene are Associated with an Inhibitory Deficit Found in Schizophrenia. (In submission).

Ross RG, Olincy A, Mikulich SK, Radant AD, Harris JG, Waldo M, Compagnon N, Heinlein S, Leonard S, Zerbe GO, Adler LE, Freedman R. Smooth Pursuit Eye Movement Measures Abnormalities in Relatives of Schizophrenic Probands (In submission)

Freedman R, Leonard S, Waldo M, Gault J, Olincy A, Adler LE, Tsuang MT, Faraone SV, Kauffman CA, Malaspina D, Svrakic D, Cloninger CR. Clinical and Molecular Characterization of Allelic Variants at Chromosome 15q14 in Schizophrenia (In submission).

Tregellas JR, Tanabe JL, Miller DE, Ross RG, Olincy A, Freedman R. Neurobiology of Smooth Pursuit Eye Movement Deficits in Schizophrenia An FMRI Study. (in submission).

What are the top three papers (not yours) you have read recently?
CATIE study
If resources were not limited, what research projects would you pursue?
alpha-7 nicotinic receptor agonists in treatment of cognition in schizophrenia
differentiation of schizophrenia from bipolar disorder through cognition
What is your leading hypothesis?
nicotinic receptor hypothesis of schizophrenia
What piece of missing evidence would help prove it?
clinical trial of alpha-7 nicotinic choliergic receptor agonist and continued search for nicotinic receptor gene
What is your fallback position?
may be multiple genes involved in schizophrenia and need to search for combinations of genes that determine who develops the illness through endophenotypes

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