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Schizophrenia Research Forum: Researcher Profile - Judith Gault
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Researcher Profile - Judith Gault

First Name:Judith
Last Name:Gault
Title:Assistant Professor
Advanced Degrees:PhD
Affiliation:University of Colorado Denver
Department:Neurosurgery and Psychiatry
Street Address 1:12700 E. 19th Ave
Street Address 2:Box 8601
Zip/Postal Code:80045
Email Address:
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Clinical Interests:
Research Focus:
Immunology, Microscopy, Molecular and Cell biology, Chemistry/pharmacology, Clinical trials, Neurotransmission, Electrophysiology, Epidemiology, GABAergic transmission, Genetics, Glia/myelin, Animal models, Bioinformatics/Statistics, Brain imaging, Cell biology, Neurodevelopment, Neuropathology, DNA microrrays, Drug screening, Phenomenology/diagnosis, Protein structure/chemistry, Proteomics, Signal transduction, Glutamatergic transmission, Pharamacology
Work Sector(s):
Reasearcher Bio

Judith Morse Gault POSITION TITLE

Assistant Professor of Neurosurgery and Psychiatry

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
(if applicable) YEAR(s) FIELD OF STUDY
San Francisco State University B.S. 9/88-6/90 Cell and Molecular
Oregon Health Sciences University Ph.D. 9/90-5/95 Mol./Medical Genetics
Univ. of Colorado Health Sciences Center Postdoc 9/95-9/01 Dev. Psychobiology/

Schizo. Genetics
A. Positions and Honors.
Positions and Employment
1986-87 General and Organic Chemistry Tutor, Skyline College Learning Center, San Bruno, CA
1986-88 Biology Lab Assistant, Skyline College Department of Biology, San Bruno, CA
1988-90 Clinical Lab Assistant, University of California, San Francisco, Microbiology Laboratories
2001- Assistant Professor, Department of Neurosurgery and Psychiatry, Univ. of CO Health Sci. Center

Other Experience
1991-95 Teaching Assistant for Medical Genetics workshops at Oregon Health Science University
2000-01 Member of the Veterans Administration Health and Safety Research Committee
1998-02 Lecture for the Molecular Biology Techniques Course, Univ. of CO Health Sci. Center
2002- Genetic advisor for the Angioma Alliance

Honors and Awards
1988 The Cadero Memorial Scholarship
1988 San Mateo Teacher's Association Scholarship
1988 Skyline's Tutorial Scholarship
1990 Best Undergraduate Poster Award at NCA-Society for Industrial Microbiology Symposium
1996-98 Developmental Psychobiology NRSA Postdoctoral Fellowship
1997 Jr. Investigator Travel Award Recipient (World Congress of Psychiatric Genetics)
1999 Invited speaker San Francisco State University, Colloquium in Cell and Molecular Biology
1999-2001 Nat. Alliance for Research on Schizophrenia and Depression Young Investigators Grant
2002- Speaker, Marine Biological Laboratories, Woods Hole, Research Update in Neuroscience for Neurosurgeons
2004 Pew Biomedical Scholars Program, UCDHSC nominee
2005 University of Pittsburgh, Visiting Professor “Genetics of Cerebral Cavernous Malformations”
Top Papers
Leonard S., Gault J., Moore T., Hopkins J., Robinson M., Olincy A., Adler L.E., Cloninger R., Kaufmann C.A., Tsuang M.T., Faraone S.V., Malaspina D., Svrakic D.M., Freedman R. (1998) Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative. Am J Med Genet 81:308-312.
Leonard S., Gault J., Adams C., Breese C.R., Rollins Y., Adler L.E., Olincy A., Freedman R. (1998) Nicotinic Receptors, Smoking and Schizophrenia (review article) Restorative Neurology and Neuroscience, 12:195-201.
Gault J., Berger R., Robinson M., Drebing C., Logel J., Hopkins J., Moore T., Jacobs S., Merriwether J., Choi M.J., Kim E.J., Walton K., Buiting K., Davis A., Breese C., Freedman R., Leonard S. (1998) Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7). Genomics 52 (2), 173-185.
Leonard S., Adler L.E., Olincy A., Breese C., Gault J., Ross R.G., Lee M., Cawthra E., Nagamoto H.T., Freedman R. The role of nicotine in psychopathology. A book chapter in “Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities” Wiley-Liss, New York. pp. 305-320, 1998.
Leonard S., Breese C., Adams C., Benhammou K., Gault J., Stevens K., Lee M., Adler L. Olincy A., Ross R., Freedman R. (2000) Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur. J. Pharm. 393:237-242.
Freedman R., Adams C., Adler L.E., Bickford P.C., Gault J., Harris J., Olincy A., Ross R.G., Stevens K., Waldo M., and Leonard S. (2000) An Inhibitory Neurophysiological Deficit as a Phenotype for Genetic Investigation of Schizophrenia. Am. J. Med Gen., Neuropsych Gen. 97:58-64.
Leonard,S., Adler,L.E., Benhammou,K., Berger,R., Breese,C.R., Drebing,C., Gault,J., Lee,M.J., Logel,J., Olincy,A., Ross,R.G., Stevens,K., Sullivan,B., Vianzon,R., Vernich,D.E., Waldo,M., Walton,K., and Freedman,R. (2001). Smoking and mental illness. Pharmacol. Biochem. Behav. 70, 561-570.
Freedman R., Leonard S., Gault J., Hopkins J., Cloninger C.R., Kaufmann C.A., Tsuang M.T., Farone, S.V., Malaspina D., Svrakic D.M., Sanders A., Gejman P. (2001) Linkage Disequilibrium for Schizophrenia at the Chromosome 15q13-14 Locus of the 7-Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7). Am J. Med Genet 105:20-22.
Leonard S., Gault J., Hopkins J., Logel J., Vianzon R., Short M., Drebing C., Berger R., Zerbe G., Olincy A., Ross R. G., Adler L.E., Freedman R. (2002) Promoter variants in the α7 nicotinic receptor subunit gene are associated with an inhibitory deficit in schizophrenia. Achieves in General Psychiatry. Arch Gen Psychiatry. 2002 Dec;59(12):1085-96.
Shenkar, R., Elliott, J.P., Diener, K., Gault, J., Hu, L.J., Cohrs, R.J., Phang, T., Hunter, L., Breeze R. E., Awad, I.A. (2003) Differential Gene Expression in Human Cerebral Vascular Malformations. Neurosurgery . 52(2):465-478.
Gault,J., Hopkins,J., Berger,R., Drebing,C., Logel,J., Walton,K., Short,M., Vianzon,R., Olincy,A., Ross,R.G., Adler,L.E., Freedman,R., and Leonard,S. (2003). Comparison of polymorphisms in the a7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. Am J Med Genet, Neuropsychiatric Genetics. 123B:39-49.
Gault J., Sarin H., Awadallah N.A., Shenkar R., Awad I.A., (2004) Pathobiology of Human Cerebral Vascular Malformations: Basic Mechanisms and Clinical Relevance. Neurosurgery. 55(1): 1-17.
What are the top three papers (not yours) you have read recently?
Lieberman et al Effectiveness of Antipsychiotic Drugs in Patients with Chronic Schizophrenia NEJM

Pieper et al. 2005 The neuroanl PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice PNAS
If resources were not limited, what research projects would you pursue?
Projects aimed at improving the treatment of patients with schizophrenia
What is your leading hypothesis?
That schizophrenia is a very complex trait and that treatment needs to be individualized

Research Participants
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