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Researcher Profile - Albert H. C. Wong |
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| First Name: | Albert H. C. | | Last Name: | Wong | | Title: | Dr. | | Advanced Degrees: | MD PhD | | Affiliation: | University of Toronto | | Department: | Psychiatry | | Street Address 1: | Centre for Addiction and Mental Health | | Street Address 2: | 250 College Street, Room 711 | | City: | Toronto | | State/Province: | Ontario | | Zip/Postal Code: | M5T 1R8 | Country/Territory: | Canada | | Phone: | 416-535-8501 | | Fax: | 416-979-4663 | | Email Address: |  |
Disclosure:
(view policy) |
Member reports no financial or other potential conflicts of interest. [Last Modified: 20 January 2007]
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View all comments by Albert H. C. Wong
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Schizophrenia, Neurodevelopmental disorders (e.g., 22q11 deletion syndromes)
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DNA microrrays, Phenomenology/diagnosis, Molecular and Cell biology, Neurodevelopment, Pharmacology, Genetics, Animal models, Neuroanatomy/Systems Neuroscience
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Research institute, University, Medical hospital
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I am currently a clinician-scientist in the Department of Psychiatry at the University of Toronto. My main interest is in using animal models to identify molecular pathways that regulate behavioural dimensions relevant to psychotic disorders. |
Semeralul MO, Boutros PC, Likhodi O, Okey AB, Van Tol HHM, Wong AHC: Microarray analysis of the developing cortex, J. Neurobiology 2006 Dec;66(14):1646-58
Wong AHC, Gottesman I, Petronis A: Phenotypic differences in genetically identical organisms: the epigenetic perspective, Human Molecular Genetics 2005; 14(R1): R11-18
Wong AHC, Lipska BK, Likhodi O, Boffa E, Weinberger DR, Kennedy JL, Van Tol HHM: Cortical gene expression in the neonatal ventral hippocampal lesion rat model, Schizophrenia Research 2005; 77(2-3):261-27
Wong AHC, Trakalo J, Likhodi O, Yusuf M, Macedo A, Azevedo M-H, Klempan T, Pato MT, Honer WG, Pato CN, Van Tol HHM, Kennedy JL: Association between schizophrenia and the syntaxin 1a gene, Biological Psychiatry 2004; 56(1):24-29
Wong AHC, et al: Identification of candidate genes for psychosis in rat models and possible association between schizophrenia and the 14-3-3eta gene. Molecular Psychiatry 2003; 8(2): 156-166 |
Hovatta I et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.
Nature. 2005 Dec 1;438(7068):662-6
Levenson JM et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J Biol Chem. 2006 Jun9;281(23): 15763-73
Meyer U et al. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci. 2006 May 3;26(18):4752-62 |
Comprehensive correlational screens of behavioural phenotype, genetic sequencing, transciptome and proteome in a battery of mouse, rat and primate models. |
There are symptom dimensions and endophenotypes that are under both genetic and epigenetic control. These interacting dimensional variables (e.g. sensory gating, susceptibility to erroneous causal inferences or working memory) combine to create clinical syndromes. Specifying the molecular regulation of these dimensions will permit development of targeted interventions for each, that will be used in combinations tailored to each patient. |
There is no single piece of evidence, but a gradual accumlation of knowledge about these specific dimensions, coming from a wide range of methods: genetics, molecular and cell biology, animal behaviour models and clinical studies. |
That some traditional diagnostic categories do exist as discrete disease entities with heterogeneous causes. |
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