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Schizophrenia Research Forum: Researcher Profile - Roger Boshes
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Researcher Profile - Roger Boshes

RESEARCHER INFORMATION
First Name:Roger
Last Name:Boshes
Advanced Degrees:MD. PhD
Affiliation:JC Corrigan Mental Health Center, Harvard Medical School
Department:Psychiatry
Street Address 1:John C Corrigan Mental Health Center
Street Address 2:49 Hillside Street
City:Fall River
State/Province:MA
Zip/Postal Code:02720
Country/Territory:U.S.A.
Phone:508 574 8456
Fax:508 235 7346
Email Address: roger.boshes@dmh.state.ma.us
Disclosure:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 10 August 2013]
View all comments by Roger Boshes
Clinical Interests:
Drug abuse, Autism spectrum disorders (pervasive developmental disorders), Schizophrenia
Research Focus:
Genetics, Pharmacology
Work Sector(s):
Community Mental Health Center
Reasearcher Bio
I have a PhD in genetics from the University of Chicago. I did a post doc in the Dept. of Mol. Biophysics and Biochem at Yale and then worked at Yale Medical School on amelanotic and melanotic melanoma. I was mentored at Mass Mental Health Center by Carl Salzman MD, worked for John Davis at Univ of Illinois, and then returned to Boston where I worked with Ross Baldessarini MD and Bruce Cohen MD, PhD. I am interested in both the genetics and treatment of patients with schizophrenia.
Top Papers
Wikswo, M. A., McGuire, J. S., Shansky, J. E., & Boshes, R. A. (1977), Nuclear Nonhistone proteins from murine melanomacells: II changes following exposure to MSH. Journal of Investigative Dermatology, 69, 516-520.

Festa, R., Meadows, A., Boshes, R. A. (1979), Leukemia in a black child with Bloom's Syndrome: Somatic recombination as a possible mechanism for neoplasia. Cancer, 44, 1507-1510.

Boshes, R. A., Manschreck, T. M., Desrosiers, J., Candela, S. F., & Hanrahan-Boshes, M.(2001), Initiation of clozapine therapy in a patient with pre-existing leukopenia: A discussion of the rationale of current treatment options. Annals of Cliniclal Psychiatry: 13(4), 233-237.

Boshes, R. A., Manschreck, T. M. (2002), Review of antipsychotic medication administration: A proposal of intermittent dosing. Schizophrenia Bulletin, 28(2), 203-222.

Manschreck, T. M., Boshes, R. A. The CATIE Trial: Results, Impact, Controversy. Harvard Review of Psychiatry, 15, 245-258.

Boshes, R. A., Manschreck, T. M., & Konigsberg, K. (2012), Genetics of the schizophrenias: A model accounting for their persistence and myriad of phenotypes. Harvard Review of Psychiatry, 20(3), 119-129.
What are the top three papers (not yours) you have read recently?
Castner, S. A., Williams, G. V., Goldman-Rakic, P. S. (2000), Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science, 287, 2020-2022.

Samaha, A.-H., Reckless, G. E., Seeman, P., Diwan, M., Nobrega, J. N. & Kapur, S. (2008), Less is more: Antipsychotic drug effects are greater with transient rather than continuous delievery. Biological Psychiatry, 64, 145-152.

Remington, G., Seeman, P., Feingold, A., Mann, S., Shammi, C. & Kaopur, S. (2010),"Extended" antipsychotic dosing in the maintenance treatment of schizophrnia: A double-blind, placebo-controlled trial.Journal of Clinical Psychiatry, 71, 1-7.
If resources were not limited, what research projects would you pursue?
Efficacy of extended/intermittent dosing of antipsychotic agents to improve or, at least, maintain outcome, reduce costs, metabolic side effects and possible minimize cognitive damage.
What is your leading hypothesis?
We do not understand how antipsychotic drugs work or how to administer them.
Moreover, we do not know anything about how to match patients with the most effective medication
What piece of missing evidence would help prove it?
See the grant I am writing
What is your fallback position?
Resubmit grant or look for another source of funding



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