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Schizophrenia Research Forum: Researcher Profile - Dennis Grayson
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Researcher Profile - Dennis Grayson

RESEARCHER INFORMATION
First Name:Dennis
Last Name:Grayson
Title:Professor of Molecular Psychiatry
Advanced Degrees:Ph.D.
Affiliation:UIC
Department:Psychiatry
Street Address 1:1601 W. Taylor St.
City:Chicago
State/Province:IL
Zip/Postal Code:60612
Country/Territory:U.S.A.
Phone:312-413-4577
Fax:312-413-4569
Email Address: 
Disclosure:
(view policy) 		 Member reports no financial or other potential conflicts of interest. [Last Modified: 17 January 2008]
View all comments by Dennis Grayson
Clinical Interests:
Autism spectrum disorders (pervasive developmental disorders), Schizophrenia, Anxiety disorders , Bipolar disorder
Research Focus:
Pharmacology, Proteomics, Pharamacology, DNA microrrays, Molecular and Cell biology, Animal models, Neurodevelopment, Neurotransmission, GABAergic transmission, Glutamatergic transmission
Work Sector(s):
University
What is your leading hypothesis?
That the etiology of schizophrenia is due to promoter hypermethylation and epigenetic dysregulation. The genes that are downregulated in key neurons of the brain are likely silenced because of epigentic factors related to promoter methylation. The observation that DNA methyltransferases are intimately associated with histone deacetylases provides a window into new protein targets that may prove to be amenable to pharmacological manipulation.
What piece of missing evidence would help prove it?
Addional methylation studies in post-mortem brain samples, particularly from concordant and discordant twins.



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