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Researcher Profile - Phil Corlett |
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| First Name: | Phil | | Last Name: | Corlett | | Title: | Dr | | Advanced Degrees: | PhD | | Affiliation: | University of Cambridge | | Department: | Psychiatry | | Street Address 1: | Downing Site | | Street Address 2: | Downing Street | | City: | Cambridge | | State/Province: | Cambridgeshire | | Zip/Postal Code: | CB2 3EB | Country/Territory: | United Kingdom | | Phone: | 0441223764674 | | Email Address: |  |
Disclosure:
(view policy) |
Member reports no financial or other potential conflicts of interest. [Last Modified: 29 November 2007]
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View all comments by Phil Corlett
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Psychology, Drug abuse, Schizophrenia
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Brain imaging, Chemistry/pharmacology, Genetics, Neuroanatomy/Systems Neuroscience, Phenomenology/diagnosis, Glutamatergic transmission
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Delusions are odd beliefs. They accompany many psychiatric illnesses, notably schizophrenia. A major challenge is to understand delusions in terms of changes in brain function. I attempted to meet this challenge by investigating the neural basis of human associative learning and belief formation, relating these processes to the formation of delusional beliefs. My findings have shaped the development of a novel mechanistic model of delusion formation.
In future work I will refine this model by applying human molecular genetic techniques and targeted pharmacological manipulations to delineate the contribution of specific neurotransmitters, as well as intracellular processes to the formation of delusions. In so doing, a fuller explanation of these puzzling symptoms in terms of genes, brain function and psychological processes will become tractable. |
1. Disrupted prediction error signal in delusions: evidence for an associative account of delusion formation
P Corlett, G Murray, G Honey, M Aitken, D Shanks, T Robbins, E Bullmore, A Dickinson, P Fletcher
Brain, In press, 2007
2. From prediction error to psychosis: ketamine as a pharmacological model of delusions
P Corlett, G Honey, P Fletcher
Journal of Psychopharmacology. 21(3):238-52 May 2007
3. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity and psychosis
P Corlett, G Honey, M Aitken, A Dickinson, D Shanks, A Absalom, M Lee, E Pomarol-Clotet, P McKenna, T Robbins, E Bullmore and P Fletcher
Arch Gen Psychiat. 63(3): 611-21 June 2006
4. Prediction Error during Retrospective Revaluation of Causal Associations in Humans: fMRI Evidence in Favor of an Associative Model of Learning
P Corlett, M Aitken, A Dickinson, D Shanks, G Honey, R Honey, T Robbins, E Bullmore and P Fletcher
Neuron. 44(5):877 - 888 December 2004
5. Brain Imaging
P Fletcher, P Corlett
In: Psychosomatic Medicine. M Blumenfield and J Strain (Eds). Chapter 50. Lippincott Williams and Wilkins
6. Psychological effects of ketamine in healthy volunteers: a phenomenological study
E Pomarol-Clotet, G Honey, G Murray, P Corlett, A Absalom, M Lee, P McKenna, E Bullmore, P Fletcher
Br. J. Psychiatry. 189:173-9. August 2006
7. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
G Honey, E Pomarol-Clotet, P Corlett, R Honey, P McKenna, E Bullmore, P Fletcher
Brain. 128:2597-611 November 2005
8. The Effects of a Subpsychotic Dose of Ketamine on Recognition and Source Memory for Agency: Implications for Pharmacological Modelling of Core Symptoms of Schizophrenia.
G Honey, C O’Loughlin, D Turner, E Pomarol-Clotet, P Corlett, P Fletcher
Neuropsychopharmacology 31(2): 413-23 August 2006
9. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
J Dalley, K Laane, D Theobald, H Armstrong, P Corlett, Y Chudasama and T Robbins
PNAS. 102(17): 6189 – 6194 April 2005
10. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning
P Fletcher, O Zafiris, C Frith, R Honey, P Corlett, K Zilles and G Fink
Cerebral Cortex. 15(7): 1002-15 July 2005
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