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Schizophrenia Research Forum: Researcher Profile - Bita Moghaddam
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Researcher Profile - Bita Moghaddam

First Name:Bita
Last Name:Moghaddam
Advanced Degrees:PhD
Affiliation:University of Pittsburgh
Street Address 1:446 Crawford Hall
Street Address 2:Department of Neuroscience
Zip/Postal Code:15260
Email Address:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 26 October 2005]
View all comments by Bita Moghaddam
Clinical Interests:
Research Focus:
Neuroanatomy/Systems Neuroscience, Glutamatergic transmission, Animal models, Electrophysiology
Work Sector(s):
Reasearcher Bio
I am interested in mechanisms that underlie cognitive control of goal-directed behavior, and how these mechanisms are disrupted in animal models of schizophrenia. Our primary focus is on the prefrontal cortex regulation of limbic regions. We study this corticolimbic interaction at presynaptic, and postsynaptic and behavioral levels by utilizing microdialysis, single unit recording in awake animals, and operant and maze-based cognitive behavioral measures.
Top Papers
Moghaddam, B. and Bunney, B.S. (1990) Acute effect of typical and atypical neuroleptics on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study, J. Neurochemistry, 54:1755-1760.

Moghaddam B., Adams B., Verma A., and Daly D. (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex, Journal of Neuroscience, 17:2921-2927.

Moghaddam B and Adams B.W. (1998) Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats, Science, 281:1349-1352.

Moghaddam B, (2003) Bringing order to the glutamate chaos in schizophrenia, Neuron, 40:881-884

Moghaddam B, Jackson ME (2004) Effect of stress on prefrontal cortex function, Neurotoxicity Research, 6:73-78

Homayoun H, Stefani MR, Adams BW, Tamagan, GD, Moghaddam B (2004) Functional interaction between NMDA and mGlu5 receptors: Effects on working memory, instrumental learning, motor behaviors, and dopamine release, Neuropsychopharmacology,. 29:1259-69

Jackson ME, Moghaddam B (2004) Stimulus-specific plasticity of prefrontal cortex dopamine neurotransmission, Journal of Neurochemistry, 88:1327-1334

Jackson ME, Homayoun H, Moghaddam, B, (2004) NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex, Proc Natl Acad Sci (USA), 101: 8467-8472

Homayoun H, Jackson ME, Moghaddam B (2005) Activation of metabotropic glutamate 2/3 (mGlu2/3) receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats, Journal of Neurophysiology, 93:1989-2001

Stefani M, Moghaddam B, Systemic and Prefrontal Cortical NMDA Receptor Blockade Differentially Affect Discrimination Learning and Set-Shift Ability in Rats, Behavioral Neurosci, 119:420-428

What are the top three papers (not yours) you have read recently?
Krystal et al., 2005 , Psychopharmacology
Bayer et al., 2005, Neuron
Dean and Murray, 2005 Dialogues Clin Neurosci
If resources were not limited, what research projects would you pursue?
Novel strategies for treatment
What is your leading hypothesis?
Glutamate hypothesis
What piece of missing evidence would help prove it?
Better imaging ligands specific for Glu receptors

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