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Researcher Profile - Bita Moghaddam |
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| First Name: | Bita | | Last Name: | Moghaddam | | Title: | Professor | | Advanced Degrees: | PhD | | Affiliation: | University of Pittsburgh | | Department: | Neuroscience | | Street Address 1: | 446 Crawford Hall | | Street Address 2: | Department of Neuroscience | | City: | Pittsburgh | | State/Province: | PA | | Zip/Postal Code: | 15260 | Country/Territory: | U.S.A. | | Phone: | 412-624-2653 | | Email Address: |  |
Disclosure:
(view policy) |
Member reports no financial or other potential conflicts of interest. [Last Modified: 26 October 2005]
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View all comments by Bita Moghaddam
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Neuroanatomy/Systems Neuroscience, Glutamatergic transmission, Animal models, Electrophysiology
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I am interested in mechanisms that underlie cognitive control of goal-directed behavior, and how these mechanisms are disrupted in animal models of schizophrenia. Our primary focus is on the prefrontal cortex regulation of limbic regions. We study this corticolimbic interaction at presynaptic, and postsynaptic and behavioral levels by utilizing microdialysis, single unit recording in awake animals, and operant and maze-based cognitive behavioral measures. |
Moghaddam, B. and Bunney, B.S. (1990) Acute effect of typical and atypical neuroleptics on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study, J. Neurochemistry, 54:1755-1760.
Moghaddam B., Adams B., Verma A., and Daly D. (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex, Journal of Neuroscience, 17:2921-2927.
Moghaddam B and Adams B.W. (1998) Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats, Science, 281:1349-1352.
Moghaddam B, (2003) Bringing order to the glutamate chaos in schizophrenia, Neuron, 40:881-884
Moghaddam B, Jackson ME (2004) Effect of stress on prefrontal cortex function, Neurotoxicity Research, 6:73-78
Homayoun H, Stefani MR, Adams BW, Tamagan, GD, Moghaddam B (2004) Functional interaction between NMDA and mGlu5 receptors: Effects on working memory, instrumental learning, motor behaviors, and dopamine release, Neuropsychopharmacology,. 29:1259-69
Jackson ME, Moghaddam B (2004) Stimulus-specific plasticity of prefrontal cortex dopamine neurotransmission, Journal of Neurochemistry, 88:1327-1334
Jackson ME, Homayoun H, Moghaddam, B, (2004) NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex, Proc Natl Acad Sci (USA), 101: 8467-8472
Homayoun H, Jackson ME, Moghaddam B (2005) Activation of metabotropic glutamate 2/3 (mGlu2/3) receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats, Journal of Neurophysiology, 93:1989-2001
Stefani M, Moghaddam B, Systemic and Prefrontal Cortical NMDA Receptor Blockade Differentially Affect Discrimination Learning and Set-Shift Ability in Rats, Behavioral Neurosci, 119:420-428
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Krystal et al., 2005 , Psychopharmacology
Bayer et al., 2005, Neuron
Dean and Murray, 2005 Dialogues Clin Neurosci |
Novel strategies for treatment |
Better imaging ligands specific for Glu receptors |
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