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Schizophrenia Research Forum: Researcher Profile - de Bartolomeis Andrea
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Researcher Profile - de Bartolomeis Andrea

First Name:de Bartolomeis
Last Name:Andrea
Title:Associate Professor
Advanced Degrees:M.D. Ph.D.
Affiliation:Laboratory of Molecular Psychiatry University of Naples Federico II
Street Address 1:Via Pansini 5
Phone:0039 081 7463673
Fax:0039 081 7462378
Email Address:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 21 January 2007]
Clinical Interests:
Research Focus:
Neurotransmission, Molecular and Cell biology, Signal transduction
Work Sector(s):
Reasearcher Bio
Andrea de Bartolomeis M.D. Ph.D, received his medical degree and his residency training in psychiatry at the University Federico II of Naples, Italy. He completed his postdoctoral fellowship in psychopharmacology and molecular pathophysiology of schizophrenia with NIMH in Bethesda MD (USA) at Clinical Neuroscience Branch (1989-1992) and at Experimental Therapeutics Branch (1993-1994) where he contributed to develop a novel method for quantitation of synaptic dopamine in vivo in primates, using PET and microdialysis simultaneously.
In 1998 he received from the University of Naples a Ph.D. degree in Methodology of Communication Science.
Dr. de Bartolomeis is currently Associate Professor of Psychiatry at Department of Neuroscience and Behavioral Sciences and Professor of Molecular Psychiatry and Psychopharmacology in the Residency Program of Clinical Psychiatry of the University Federico II of Naples.
He is Chief of the Laboratory of Molecular Psychiatry and he is in charge of the Outpatient Clinics for Treatment Resistant Psychosis. The research interest of Andrea de Bartolomeis include the molecular pathophysiology of psychosis, CNS gene expression modulation by psychotropic drugs, and augmentation strategy in psychosis pharmacotherapy.
He has been principal investigator or co-investigator on several research and training grants as well on clinical trials from public and drug company sources.
He has authored many papers, book chapters and published abstracts on molecular mechanisms of antipsychotics as well as on schizophrenia pathophysiology and molecular imaging of dopaminergic system. He published his works in leading journals including Nature in Medicine, Proceedings of national Academy of Sciences, Biological Psychiatry, Neuropsychopharmacology, MoleculaR Brain Research, Synapse, Cerebral Blood FLOW and Metabolism .
His recent research is focusing on antipsychotics impact on postsynaptic density scaffolding proteins and molecular mechanisms of antipsychotics augmentation by glicine partial agonists.

Top Papers
1: de Bartolomeis A, Fiore G, Iasevoli F. Related Articles, Links
Dopamine-glutamate interaction and antipsychotics mechanism of action: implication for new pharmacological strategies in psychosis.
Curr Pharm Des. 2005;11(27):3561-94.
PMID: 16248808 [PubMed - in process]
2 Boscia F, Gala R, Pignataro G, de Bartolomeis A, Cicale M, Ambesi-Impiombato A, Di Renzo G, Annunziato L. Related Articles, Links
Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na(+)/Ca(2+) exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.
J Cereb Blood Flow Metab. 2005 Aug 17; [Epub ahead of print]
PMID: 16107787 [PubMed - as supplied by publisher]
3. Tiraboschi E, Giambelli R, D'Urso G, Galietta A, Barbon A, de Bartolomeis A, Gennarelli M, Barlati S, Racagni G, Popoli M. Related Articles, Links
Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation.
Neuroreport. 2004 Oct 25;15(15):2393-6.
PMID: 15640762 [PubMed - indexed for MEDLINE]
4. de Bartolomeis A, Fiore G. Related Articles, Links
Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: implications for human behavior pathologies.
Int Rev Neurobiol. 2004;59:221-54. Review.
PMID: 15006490 [PubMed - indexed for MEDLINE]

5: de Bartolomeis A, Iasevoli F. Related Articles, Links
The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapy.
Psychopharmacol Bull. 2003 Summer;37(3):51-83. Review.
PMID: 14608240 [PubMed - indexed for MEDLINE]

6 Ambesi-Impiombato A, D'Urso G, Muscettola G, de Bartolomeis A. Related Articles, Links
Method for quantitative in situ hybridization histochemistry and image analysis applied for Homer1a gene expression in rat brain.
Brain Res Brain Res Protoc. 2003 Jul;11(3):189-96.
PMID: 12842224 [PubMed - indexed for MEDLINE]

8: Celano E, Tiraboschi E, Consogno E, D'Urso G, Mbakop MP, Gennarelli M, de Bartolomeis A, Racagni G, Popoli M. Related Articles, Links
Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs.
Biol Psychiatry. 2003 Mar 1;53(5):442-9.
PMID: 12614997 [PubMed - indexed for MEDLINE]
9 Polese D, de Serpis AA, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A. Related Articles., Links
Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine.
Neuropsychopharmacology. 2002 Dec;27(6):906-13.
PMID: 12464447 [PubMed - indexed for MEDLINE]
10. Cicale M, Ambesi-Impiombato A, Cimini V, Fiore G, Muscettola G, Abbott LC, de Bartolomeis A. Related Articles, Links
Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice.
Brain Res Bull. 2002 Oct 15;59(1):53-8.
PMID: 12372549 [PubMed - indexed for MEDLINE]
11.: de Bartolomeis A, Aloj L, Ambesi-Impiombato A, Bravi D, Caraco C, Muscettola G, Barone P. Related Articles, Links
Acute administration of antipsychotics modulates Homer striatal gene expression differentially.
Brain Res Mol Brain Res. 2002 Jan 31;98(1-2):124-9.
PMID: 11834303 [PubMed - indexed for MEDLINE]

12.Carbone M, Rizzo P, Grimley PM, Procopio A, Mew DJ, Shridhar V, de Bartolomeis A, Esposito V, Giuliano MT, Steinberg SM, Levine AS, Giordano A, Pass HI. Related Articles, Links
Simian virus-40 large-T antigen binds p53 in human mesotheliomas.
Nat Med. 1997 Aug;3(8):908-12.
What are the top three papers (not yours) you have read recently?
1: Szumlinski KK, Lominac KD, Kleschen MJ, Oleson EB, Dehoff MH, Schwartz MK, Seeberg PH, Worley PF, Kalivas PW. Related Articles, Links
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.
Genes Brain Behav. 2005 Jul;4(5):273-88.
PMID: 16011574 [PubMed - indexed for MEDLINE]

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